Targeted therapy for non-small cell lung cancer.
Publication
, Journal Article
Toloza, EM; D'Amico, TA
Published in: Semin Thorac Cardiovasc Surg
2005
The overall survival for the treatment of lung cancer patients is less than 15%, despite advances in chemotherapy, radiation therapy, and surgery, due to the inability to control metastatic disease. Over the past three decades, the genetics of lung cancer has been progressively delineated. Small molecule drugs or monoclonal antibodies have been developed that target and inactivate specific cancer-related proteins, such as growth factor receptors or their kinases. This article will review the therapeutic implications of molecular changes associated with non-small cell lung cancer and the status of targeted therapies in its treatment.
Duke Scholars
Published In
Semin Thorac Cardiovasc Surg
DOI
ISSN
1043-0679
Publication Date
2005
Volume
17
Issue
3
Start / End Page
199 / 204
Location
United States
Related Subject Headings
- Respiratory System
- Receptors, Vascular Endothelial Growth Factor
- Proto-Oncogene Proteins p21(ras)
- NF-kappa B
- Lung Neoplasms
- Humans
- ErbB Receptors
- Carcinoma, Non-Small-Cell Lung
- Antineoplastic Agents
- 3202 Clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Toloza, E. M., & D’Amico, T. A. (2005). Targeted therapy for non-small cell lung cancer. Semin Thorac Cardiovasc Surg, 17(3), 199–204. https://doi.org/10.1053/j.semtcvs.2005.08.001
Toloza, Eric M., and Thomas A. D’Amico. “Targeted therapy for non-small cell lung cancer.” Semin Thorac Cardiovasc Surg 17, no. 3 (2005): 199–204. https://doi.org/10.1053/j.semtcvs.2005.08.001.
Toloza EM, D’Amico TA. Targeted therapy for non-small cell lung cancer. Semin Thorac Cardiovasc Surg. 2005;17(3):199–204.
Toloza, Eric M., and Thomas A. D’Amico. “Targeted therapy for non-small cell lung cancer.” Semin Thorac Cardiovasc Surg, vol. 17, no. 3, 2005, pp. 199–204. Pubmed, doi:10.1053/j.semtcvs.2005.08.001.
Toloza EM, D’Amico TA. Targeted therapy for non-small cell lung cancer. Semin Thorac Cardiovasc Surg. 2005;17(3):199–204.
Published In
Semin Thorac Cardiovasc Surg
DOI
ISSN
1043-0679
Publication Date
2005
Volume
17
Issue
3
Start / End Page
199 / 204
Location
United States
Related Subject Headings
- Respiratory System
- Receptors, Vascular Endothelial Growth Factor
- Proto-Oncogene Proteins p21(ras)
- NF-kappa B
- Lung Neoplasms
- Humans
- ErbB Receptors
- Carcinoma, Non-Small-Cell Lung
- Antineoplastic Agents
- 3202 Clinical sciences