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Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer.

Publication ,  Journal Article
Peedicayil, A; Vierkant, RA; Shridhar, V; Schildkraut, JM; Armasu, S; Hartmann, LC; Fridley, BL; Cunningham, JM; Phelan, CM; Sellers, TA; Goode, EL
Published in: Gynecol Oncol
August 2009

OBJECTIVE: We have previously shown that TCEAL7 (transcription elongation factor A (SII)-like 7) is epigenetically down-regulated in the majority of epithelial ovarian cancers. We now examine the hypothesis that inherited alterations in TCEAL7 play a role in the etiology of ovarian cancer. METHODS: A two-site case-control study of 930 cases of ovarian cancer and 1037 controls, frequency-matched on residence, age and race, was conducted. Six informative SNPs (tagSNPs and putative-functional SNPs) were genotyped. Logistic regression was used to adjust for potential confounders and determine if inherited variation at this locus was associated with risk of ovarian cancer in general and among cases with invasive disease and serous histology. Gene-level principal component and haplotype analyses were also conducted. RESULTS: None of the SNPs or haplotypes studied were significantly associated with ovarian cancer risk overall. However, among the 440 invasive serous cases, the minor alleles for three correlated SNPs were significantly associated with reduced risk (p-values<0.05), summarized gene-level variation was weakly associated with reduced risk (p-value=0.05), and the predominant haplotype was less common among cases than controls (0.36 v 0.40, p-value=0.05), consistent with single-SNP results. CONCLUSION: TCEAL7 polymorphisms may play a role in the development of invasive serous ovarian cancers. Follow-up molecular and replication studies are warranted.

Duke Scholars

Published In

Gynecol Oncol

DOI

EISSN

1095-6859

Publication Date

August 2009

Volume

114

Issue

2

Start / End Page

260 / 264

Location

United States

Related Subject Headings

  • Young Adult
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Neoplasm Staging
  • Middle Aged
  • Humans
  • Genetic Predisposition to Disease
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Peedicayil, A., Vierkant, R. A., Shridhar, V., Schildkraut, J. M., Armasu, S., Hartmann, L. C., … Goode, E. L. (2009). Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer. Gynecol Oncol, 114(2), 260–264. https://doi.org/10.1016/j.ygyno.2009.03.038
Peedicayil, Abraham, Robert A. Vierkant, Vijayalakshmi Shridhar, Joellen M. Schildkraut, Sebastian Armasu, Lynn C. Hartmann, Brooke L. Fridley, et al. “Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer.Gynecol Oncol 114, no. 2 (August 2009): 260–64. https://doi.org/10.1016/j.ygyno.2009.03.038.
Peedicayil A, Vierkant RA, Shridhar V, Schildkraut JM, Armasu S, Hartmann LC, et al. Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer. Gynecol Oncol. 2009 Aug;114(2):260–4.
Peedicayil, Abraham, et al. “Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer.Gynecol Oncol, vol. 114, no. 2, Aug. 2009, pp. 260–64. Pubmed, doi:10.1016/j.ygyno.2009.03.038.
Peedicayil A, Vierkant RA, Shridhar V, Schildkraut JM, Armasu S, Hartmann LC, Fridley BL, Cunningham JM, Phelan CM, Sellers TA, Goode EL. Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer. Gynecol Oncol. 2009 Aug;114(2):260–264.
Journal cover image

Published In

Gynecol Oncol

DOI

EISSN

1095-6859

Publication Date

August 2009

Volume

114

Issue

2

Start / End Page

260 / 264

Location

United States

Related Subject Headings

  • Young Adult
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Neoplasm Staging
  • Middle Aged
  • Humans
  • Genetic Predisposition to Disease
  • Female