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Aptamer applications for targeted cancer therapy.

Publication ,  Journal Article
Barbas, AS; Mi, J; Clary, BM; White, RR
Published in: Future Oncol
July 2010

Aptamers are single-stranded DNA or RNA oligonucleotides that assume specific 3D structures and bind to target molecules with high affinity. The unique specificity of aptamers has made them attractive agents for targeted cancer therapy. Aptamers have been developed against a variety of cancer targets, including extracellular ligands and cell surface proteins. In addition, aptamers have been incorporated into novel constructs involving siRNAs, chemotherapeutic agents, cell toxins and nanoparticles, in which they function as delivery agents for therapeutic cargo. In this article, we review recent developments in the use of aptamers for targeted cancer therapy, particularly focusing on novel applications of aptamers targeting the cell surface.

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Published In

Future Oncol

DOI

EISSN

1744-8301

Publication Date

July 2010

Volume

6

Issue

7

Start / End Page

1117 / 1126

Location

England

Related Subject Headings

  • SELEX Aptamer Technique
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Drug Delivery Systems
  • Aptamers, Nucleotide
  • Antineoplastic Agents
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Barbas, A. S., Mi, J., Clary, B. M., & White, R. R. (2010). Aptamer applications for targeted cancer therapy. Future Oncol, 6(7), 1117–1126. https://doi.org/10.2217/fon.10.67
Barbas, Andrew S., Jing Mi, Bryan M. Clary, and Rebekah R. White. “Aptamer applications for targeted cancer therapy.Future Oncol 6, no. 7 (July 2010): 1117–26. https://doi.org/10.2217/fon.10.67.
Barbas AS, Mi J, Clary BM, White RR. Aptamer applications for targeted cancer therapy. Future Oncol. 2010 Jul;6(7):1117–26.
Barbas, Andrew S., et al. “Aptamer applications for targeted cancer therapy.Future Oncol, vol. 6, no. 7, July 2010, pp. 1117–26. Pubmed, doi:10.2217/fon.10.67.
Barbas AS, Mi J, Clary BM, White RR. Aptamer applications for targeted cancer therapy. Future Oncol. 2010 Jul;6(7):1117–1126.
Journal cover image

Published In

Future Oncol

DOI

EISSN

1744-8301

Publication Date

July 2010

Volume

6

Issue

7

Start / End Page

1117 / 1126

Location

England

Related Subject Headings

  • SELEX Aptamer Technique
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Drug Delivery Systems
  • Aptamers, Nucleotide
  • Antineoplastic Agents
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis