In vivo selection of tumor-targeting RNA motifs.
Publication
, Journal Article
Mi, J; Liu, Y; Rabbani, ZN; Yang, Z; Urban, JH; Sullenger, BA; Clary, BM
Published in: Nat Chem Biol
January 2010
In an effort to target the in vivo context of tumor-specific moieties, we screened a large library of nuclease-resistant RNA oligonucleotides in tumor-bearing mice to identify candidate molecules with the ability to localize to hepatic colon cancer metastases. One of the selected molecules is an RNA aptamer that binds to p68, an RNA helicase that has been shown to be upregulated in colorectal cancer.
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Published In
Nat Chem Biol
DOI
EISSN
1552-4469
Publication Date
January 2010
Volume
6
Issue
1
Start / End Page
22 / 24
Location
United States
Related Subject Headings
- RNA
- Oligonucleotides
- Neoplasms
- Neoplasm Metastasis
- Mice
- Liver Neoplasms
- Kinetics
- Humans
- Genetic Techniques
- Gene Expression Regulation, Neoplastic
Citation
APA
Chicago
ICMJE
MLA
NLM
Mi, J., Liu, Y., Rabbani, Z. N., Yang, Z., Urban, J. H., Sullenger, B. A., & Clary, B. M. (2010). In vivo selection of tumor-targeting RNA motifs. Nat Chem Biol, 6(1), 22–24. https://doi.org/10.1038/nchembio.277
Mi, Jing, Yingmiao Liu, Zahid N. Rabbani, Zhongguang Yang, Johannes H. Urban, Bruce A. Sullenger, and Bryan M. Clary. “In vivo selection of tumor-targeting RNA motifs.” Nat Chem Biol 6, no. 1 (January 2010): 22–24. https://doi.org/10.1038/nchembio.277.
Mi J, Liu Y, Rabbani ZN, Yang Z, Urban JH, Sullenger BA, et al. In vivo selection of tumor-targeting RNA motifs. Nat Chem Biol. 2010 Jan;6(1):22–4.
Mi, Jing, et al. “In vivo selection of tumor-targeting RNA motifs.” Nat Chem Biol, vol. 6, no. 1, Jan. 2010, pp. 22–24. Pubmed, doi:10.1038/nchembio.277.
Mi J, Liu Y, Rabbani ZN, Yang Z, Urban JH, Sullenger BA, Clary BM. In vivo selection of tumor-targeting RNA motifs. Nat Chem Biol. 2010 Jan;6(1):22–24.
Published In
Nat Chem Biol
DOI
EISSN
1552-4469
Publication Date
January 2010
Volume
6
Issue
1
Start / End Page
22 / 24
Location
United States
Related Subject Headings
- RNA
- Oligonucleotides
- Neoplasms
- Neoplasm Metastasis
- Mice
- Liver Neoplasms
- Kinetics
- Humans
- Genetic Techniques
- Gene Expression Regulation, Neoplastic