A coalescent model for the effect of advantageous mutations on the genealogy of a population
When an advantageous mutation occurs in a population, the favorable allele may spread to the entire population in a short time, an event known as a selective sweep. As a result, when we sample n individuals from a population and trace their ancestral lines backwards in time, many lineages may coalesce almost instantaneously at the time of a selective sweep. We show that as the population size goes to infinity, this process converges to a coalescent process called a coalescent with multiple collisions. A better approximation for finite populations can be obtained using a coalescent with simultaneous multiple collisions. We also show how these coalescent approximations can be used to get insight into how beneficial mutations affect the behavior of statistics that have been used to detect departures from the usual Kingman's coalescent. © 2005 Elsevier B.V. All rights reserved.
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- Statistics & Probability
- 4905 Statistics
- 4901 Applied mathematics
- 1502 Banking, Finance and Investment
- 0104 Statistics
- 0102 Applied Mathematics
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Statistics & Probability
- 4905 Statistics
- 4901 Applied mathematics
- 1502 Banking, Finance and Investment
- 0104 Statistics
- 0102 Applied Mathematics