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Impact of preepiglottic space tumor involvement on concurrent chemoradiation therapy.

Publication ,  Journal Article
Lee, WT; Rizzi, M; Scharpf, J; Lorenz, RR; Saxton, JP; Adelstein, DJ; Esclamado, RM
Published in: Am J Otolaryngol
2010

PURPOSE: The aim of the study was to determine the prognostic impact of preepiglottic space (PES) involvement on local failure after concurrent chemoradiation therapy for squamous cell carcinoma. MATERIALS AND METHODS: Retrospective chart review of patients who underwent concurrent chemoradiation therapy for T3 or T4 laryngeal, T4 hypopharyngeal, and T3 or T4 oropharyngeal squamous cell carcinoma were eligible for inclusion. Patients were then stratified by the presence or absence of PES tumor involvement. A multivariate analysis was performed on the presence of recurrence using the following pretreatment variables: PES involvement, tumor extent, pathologic cell differentiation, lymph node involvement, age, and sex. RESULTS: A total of 102 patients were included in the study. Twenty-seven (28%) patients had documented PES involvement. Mean follow-up for all patients was 46 months. Involvement of the PES was not significantly associated with local tumor persistence or recurrence (P = .69). No other variables significantly impacted tumor recurrence. CONCLUSION: Preepiglottic space involvement does not negatively impact local tumor control after concurrent chemoradiation therapy.

Duke Scholars

Published In

Am J Otolaryngol

DOI

EISSN

1532-818X

Publication Date

2010

Volume

31

Issue

3

Start / End Page

185 / 188

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Recurrence
  • Prognosis
  • Otorhinolaryngology
  • Oropharyngeal Neoplasms
  • Neoplasm Staging
  • Neoplasm Metastasis
  • Multivariate Analysis
  • Male
  • Laryngeal Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lee, W. T., Rizzi, M., Scharpf, J., Lorenz, R. R., Saxton, J. P., Adelstein, D. J., & Esclamado, R. M. (2010). Impact of preepiglottic space tumor involvement on concurrent chemoradiation therapy. Am J Otolaryngol, 31(3), 185–188. https://doi.org/10.1016/j.amjoto.2009.02.001
Lee, Walter T., Mark Rizzi, Joseph Scharpf, Robert R. Lorenz, Jerrod P. Saxton, David J. Adelstein, and Ramon M. Esclamado. “Impact of preepiglottic space tumor involvement on concurrent chemoradiation therapy.Am J Otolaryngol 31, no. 3 (2010): 185–88. https://doi.org/10.1016/j.amjoto.2009.02.001.
Lee WT, Rizzi M, Scharpf J, Lorenz RR, Saxton JP, Adelstein DJ, et al. Impact of preepiglottic space tumor involvement on concurrent chemoradiation therapy. Am J Otolaryngol. 2010;31(3):185–8.
Lee, Walter T., et al. “Impact of preepiglottic space tumor involvement on concurrent chemoradiation therapy.Am J Otolaryngol, vol. 31, no. 3, 2010, pp. 185–88. Pubmed, doi:10.1016/j.amjoto.2009.02.001.
Lee WT, Rizzi M, Scharpf J, Lorenz RR, Saxton JP, Adelstein DJ, Esclamado RM. Impact of preepiglottic space tumor involvement on concurrent chemoradiation therapy. Am J Otolaryngol. 2010;31(3):185–188.
Journal cover image

Published In

Am J Otolaryngol

DOI

EISSN

1532-818X

Publication Date

2010

Volume

31

Issue

3

Start / End Page

185 / 188

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Recurrence
  • Prognosis
  • Otorhinolaryngology
  • Oropharyngeal Neoplasms
  • Neoplasm Staging
  • Neoplasm Metastasis
  • Multivariate Analysis
  • Male
  • Laryngeal Neoplasms