Mutant metabolic enzymes are at the origin of gliomas.
Publication
, Journal Article
Yan, H; Bigner, DD; Velculescu, V; Parsons, DW
Published in: Cancer Res
December 15, 2009
Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas and oligodendrogliomas. All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1 and the analogous R172 residue of IDH2). IDH1 and IDH2 mutations define a specific subtype of gliomas and may have significant utility for the diagnosis, prognosis, and treatment of patients with these tumors.
Duke Scholars
Published In
Cancer Res
DOI
EISSN
1538-7445
Publication Date
December 15, 2009
Volume
69
Issue
24
Start / End Page
9157 / 9159
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Mutation
- Isocitrate Dehydrogenase
- Humans
- Glioblastoma
- Central Nervous System Neoplasms
- Astrocytoma
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Yan, H., Bigner, D. D., Velculescu, V., & Parsons, D. W. (2009). Mutant metabolic enzymes are at the origin of gliomas. Cancer Res, 69(24), 9157–9159. https://doi.org/10.1158/0008-5472.CAN-09-2650
Yan, Hai, Darell D. Bigner, Victor Velculescu, and D Williams Parsons. “Mutant metabolic enzymes are at the origin of gliomas.” Cancer Res 69, no. 24 (December 15, 2009): 9157–59. https://doi.org/10.1158/0008-5472.CAN-09-2650.
Yan H, Bigner DD, Velculescu V, Parsons DW. Mutant metabolic enzymes are at the origin of gliomas. Cancer Res. 2009 Dec 15;69(24):9157–9.
Yan, Hai, et al. “Mutant metabolic enzymes are at the origin of gliomas.” Cancer Res, vol. 69, no. 24, Dec. 2009, pp. 9157–59. Pubmed, doi:10.1158/0008-5472.CAN-09-2650.
Yan H, Bigner DD, Velculescu V, Parsons DW. Mutant metabolic enzymes are at the origin of gliomas. Cancer Res. 2009 Dec 15;69(24):9157–9159.
Published In
Cancer Res
DOI
EISSN
1538-7445
Publication Date
December 15, 2009
Volume
69
Issue
24
Start / End Page
9157 / 9159
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Mutation
- Isocitrate Dehydrogenase
- Humans
- Glioblastoma
- Central Nervous System Neoplasms
- Astrocytoma
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology
- 1112 Oncology and Carcinogenesis