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Analysis of trends in antimicrobial resistance patterns among clinical isolates of Bacteroides fragilis group species from 1990 to 1994.

Publication ,  Journal Article
Snydman, DR; McDermott, L; Cuchural, GJ; Hecht, DW; Iannini, PB; Harrell, LJ; Jenkins, SG; O'Keefe, JP; Pierson, CL; Rihs, JD; Yu, VL ...
Published in: Clin Infect Dis
December 1996

Antimicrobial resistance, including plasmid-mediated resistance, among Bacteroides fragilis group species is well documented. A 5-year (1990-1994) prospective, eight-center survey of 3,177 clinical isolates of Bacteroides species was undertaken to review trends in resistance, using the breakpoints for full and intermediate susceptibility established by the National Committee for Clinical Laboratory Standards. No documented resistance to either metronidazole or chloramphenicol was found in this survey. Among B. fragilis isolates virtually no resistance was seen to imipenem, meropenem, ampicillin/sulbactam, piperacillin/tazobactam, or ticarcillin/clavulanate. Significant increases in resistance among B. fragilis isolates to cefotetan, ceftizoxime, and clindamycin (p < .01) were noted. Resistance to cefoxitin remained unchanged. Among the non-fragilis species of the B. fragilis group, there was virtually no resistance to imipenem, meropenem, chloramphenicol, or metronidazole. The three beta-lactamase inhibitors had increasing levels of resistance, although 95%-98% of strains were susceptible (p < .05). There was a significant decline in cefoxitin, cefmetazole, and clindamycin activity over time against these strains (p <.01). There was a significant (P < .001) increase in geometric mean minimum inhibitory concentration for most drugs and species tested from 1990 to 1994. Clusters in the eight institutions could not account for this rise in resistance. This survey demonstrates that rates of resistance of B. fragilis and non-fragilis species of B. fragilis group are increasing.

Duke Scholars

Published In

Clin Infect Dis

DOI

ISSN

1058-4838

Publication Date

December 1996

Volume

23 Suppl 1

Start / End Page

S54 / S65

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Species Specificity
  • Prospective Studies
  • Microbiology
  • Humans
  • Drug Resistance, Microbial
  • Data Collection
  • Bacteroides fragilis
  • Bacteroides Infections
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Snydman, D. R., McDermott, L., Cuchural, G. J., Hecht, D. W., Iannini, P. B., Harrell, L. J., … Gorbach, S. L. (1996). Analysis of trends in antimicrobial resistance patterns among clinical isolates of Bacteroides fragilis group species from 1990 to 1994. Clin Infect Dis, 23 Suppl 1, S54–S65. https://doi.org/10.1093/clinids/23.supplement_1.s54
Snydman, D. R., L. McDermott, G. J. Cuchural, D. W. Hecht, P. B. Iannini, L. J. Harrell, S. G. Jenkins, et al. “Analysis of trends in antimicrobial resistance patterns among clinical isolates of Bacteroides fragilis group species from 1990 to 1994.Clin Infect Dis 23 Suppl 1 (December 1996): S54–65. https://doi.org/10.1093/clinids/23.supplement_1.s54.
Snydman DR, McDermott L, Cuchural GJ, Hecht DW, Iannini PB, Harrell LJ, et al. Analysis of trends in antimicrobial resistance patterns among clinical isolates of Bacteroides fragilis group species from 1990 to 1994. Clin Infect Dis. 1996 Dec;23 Suppl 1:S54–65.
Snydman, D. R., et al. “Analysis of trends in antimicrobial resistance patterns among clinical isolates of Bacteroides fragilis group species from 1990 to 1994.Clin Infect Dis, vol. 23 Suppl 1, Dec. 1996, pp. S54–65. Pubmed, doi:10.1093/clinids/23.supplement_1.s54.
Snydman DR, McDermott L, Cuchural GJ, Hecht DW, Iannini PB, Harrell LJ, Jenkins SG, O’Keefe JP, Pierson CL, Rihs JD, Yu VL, Finegold SM, Gorbach SL. Analysis of trends in antimicrobial resistance patterns among clinical isolates of Bacteroides fragilis group species from 1990 to 1994. Clin Infect Dis. 1996 Dec;23 Suppl 1:S54–S65.

Published In

Clin Infect Dis

DOI

ISSN

1058-4838

Publication Date

December 1996

Volume

23 Suppl 1

Start / End Page

S54 / S65

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Species Specificity
  • Prospective Studies
  • Microbiology
  • Humans
  • Drug Resistance, Microbial
  • Data Collection
  • Bacteroides fragilis
  • Bacteroides Infections