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Intracardiac transplantation of a mixed population of bone marrow cells improves both regional systolic contractility and diastolic relaxation.

Publication ,  Journal Article
Thompson, RB; van den Bos, EJ; Davis, BH; Morimoto, Y; Craig, D; Sutton, BS; Glower, DD; Taylor, DA
Published in: J Heart Lung Transplant
February 2005

BACKGROUND: Pre-clinical and clinical studies suggest that transplantation of bone marrow-derived stem cells can improve global cardiac function. However, no quantitative assessment of regional systolic contraction and correlation with phenotype has been made. Therefore, we used our model of cryoinfarcted rabbit myocardium for intracardiac transplantation of a mixed population of bone marrow-derived cells and assessed both regional function and myogenic conversion of the cells. METHODS: Nineteen New Zealand white rabbits underwent cryoinjury of the left ventricle. Autologous bone marrow (BM) cells were expanded in vitro. After 2 weeks, either 1 x 10(8) mixed BM-derived progenitor cells (BM group, n = 11) or vehicle (control group, n = 8) were injected into the cryoinjured region. Regional systolic function was measured using micromanometry and sonomicrometry before and 4 weeks after cell injection; cell phenotype was evaluated histologically. RESULTS: All animals in the BM group significantly improved both systolic shortening (0.11 +/- 0.7 vs -0.05 +/- 0.05 mm in the control group, p < 0.05) and regional stroke work when compared with control (9.6 +/- 2.4 vs -1.2 +/- 1.2 mm . mm Hg, p < 0.003). In addition, the BM group had improved global diastolic function, as measured by minimum dP/dt and end-diastolic pressure. On histologic assessment, BM cells differentiated toward a myogenic phenotype. CONCLUSIONS: Transplanting a mixed population of marrow-derived cells that can adopt a myogenic phenotype improves regional contractility and diastolic relaxation after myocardial infarction.

Duke Scholars

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Published In

J Heart Lung Transplant

DOI

ISSN

1053-2498

Publication Date

February 2005

Volume

24

Issue

2

Start / End Page

205 / 214

Location

United States

Related Subject Headings

  • Surgery
  • Stroke Volume
  • Rabbits
  • Phenotype
  • Myocardium
  • Myocardial Infarction
  • Myocardial Contraction
  • Mesenchymal Stem Cell Transplantation
  • Heart Ventricles
  • Heart Transplantation
 

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Thompson, R. B., van den Bos, E. J., Davis, B. H., Morimoto, Y., Craig, D., Sutton, B. S., … Taylor, D. A. (2005). Intracardiac transplantation of a mixed population of bone marrow cells improves both regional systolic contractility and diastolic relaxation. J Heart Lung Transplant, 24(2), 205–214. https://doi.org/10.1016/j.healun.2003.10.021
Thompson, Richard B., Ewout J. van den Bos, Bryce H. Davis, Yoshihisa Morimoto, Damian Craig, Brad S. Sutton, Donald D. Glower, and Doris A. Taylor. “Intracardiac transplantation of a mixed population of bone marrow cells improves both regional systolic contractility and diastolic relaxation.J Heart Lung Transplant 24, no. 2 (February 2005): 205–14. https://doi.org/10.1016/j.healun.2003.10.021.
Thompson RB, van den Bos EJ, Davis BH, Morimoto Y, Craig D, Sutton BS, et al. Intracardiac transplantation of a mixed population of bone marrow cells improves both regional systolic contractility and diastolic relaxation. J Heart Lung Transplant. 2005 Feb;24(2):205–14.
Thompson, Richard B., et al. “Intracardiac transplantation of a mixed population of bone marrow cells improves both regional systolic contractility and diastolic relaxation.J Heart Lung Transplant, vol. 24, no. 2, Feb. 2005, pp. 205–14. Pubmed, doi:10.1016/j.healun.2003.10.021.
Thompson RB, van den Bos EJ, Davis BH, Morimoto Y, Craig D, Sutton BS, Glower DD, Taylor DA. Intracardiac transplantation of a mixed population of bone marrow cells improves both regional systolic contractility and diastolic relaxation. J Heart Lung Transplant. 2005 Feb;24(2):205–214.
Journal cover image

Published In

J Heart Lung Transplant

DOI

ISSN

1053-2498

Publication Date

February 2005

Volume

24

Issue

2

Start / End Page

205 / 214

Location

United States

Related Subject Headings

  • Surgery
  • Stroke Volume
  • Rabbits
  • Phenotype
  • Myocardium
  • Myocardial Infarction
  • Myocardial Contraction
  • Mesenchymal Stem Cell Transplantation
  • Heart Ventricles
  • Heart Transplantation