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Ethnic differences in coronary artery calcium in a healthy cohort aged 60 to 69 years.

Publication ,  Journal Article
Fair, JM; Kiazand, A; Varady, A; Mahbouba, M; Norton, L; Rubin, GD; Iribarren, C; Go, AS; Hlatky, MA; Fortmann, SP
Published in: Am J Cardiol
September 15, 2007

Measurement of coronary artery calcium (CAC) has been proposed as a screening tool, but CAC levels may differ according to race and gender. Racial/ethnic and gender distributions of CAC were examined in a randomly selected cohort of 60- to 69-year-old healthy subjects. Demographic, race/ethnicity (R/E), and clinical characteristics and assessment of CAC were collected. There were 723 white/European, 105 African-American, 73 Hispanic, and 67 East Asian subjects (597 men, 369 women) included in this analysis. Men had a significantly higher prevalence of any CAC (score>10) than women (76% vs 41%; p<0.0001). For men, the unadjusted odds of having any CAC was 2.2 (95% confidence interval [CI] 1.3 to 3.8) for whites compared with African-Americans. For women, CAC scores were not significantly different across ethnic groups. After adjustment for coronary risk factors, African-American and East Asian R/E remained associated with a lower prevalence of CAC in men (adjusted odds ratios [ORs] 0.33 and 0.47, respectively), as well as older age (OR 1.2, 95% CI 1.1 to 1.3), known hyperlipidemia (OR 1.7, 95% CI 1.1 to 2.7), and history of hypertension (OR 2.2, 95% CI 1.4 to 3.3). In women, Asian R/E (OR 2.5, 95% CI 1.1 to 5.7), history of smoking (adjusted OR 2.8, 95% CI 1.3 to 6.1), and known hyperlipidemia (adjusted OR 2.0, 95% CI 1.3 to 3.1) were associated with a higher prevalence of CAC independent of other risk factors. In conclusion, our data indicate that the presence of CAC varied significantly across selected race/ethnic groups independent of traditional cardiovascular risk factors.

Duke Scholars

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

September 15, 2007

Volume

100

Issue

6

Start / End Page

981 / 985

Location

United States

Related Subject Headings

  • White People
  • Reference Values
  • Odds Ratio
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Female
  • Ethnicity
  • Cross-Sectional Studies
 

Citation

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Fair, J. M., Kiazand, A., Varady, A., Mahbouba, M., Norton, L., Rubin, G. D., … Fortmann, S. P. (2007). Ethnic differences in coronary artery calcium in a healthy cohort aged 60 to 69 years. Am J Cardiol, 100(6), 981–985. https://doi.org/10.1016/j.amjcard.2007.04.038
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

September 15, 2007

Volume

100

Issue

6

Start / End Page

981 / 985

Location

United States

Related Subject Headings

  • White People
  • Reference Values
  • Odds Ratio
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Female
  • Ethnicity
  • Cross-Sectional Studies