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Sprinter: a novel transmembrane protein required for Wg secretion and signaling.

Publication ,  Journal Article
Goodman, RM; Thombre, S; Firtina, Z; Gray, D; Betts, D; Roebuck, J; Spana, EP; Selva, EM
Published in: Development (Cambridge, England)
December 2006

Wingless (Wg) is a secreted ligand that differentially activates gene expression in target tissues. It belongs to the Wnt family of secreted signaling molecules that regulate cell-to-cell interactions during development. Activation of Wg targets is dependent on the ligand concentration in the extracellular milieu; cellular mechanisms that govern the synthesis, delivery and receipt of Wg are elaborate and complex. We have identified sprinter (srt), which encodes a novel, evolutionarily conserved transmembrane protein required for the transmission of the Wg signal. Mutations in srt cause the accumulation of Wg in cells that express it, and retention of the ligand prevents activation of its target genes in signal-receiving cells. In the absence of Srt activity, levels of Wg targets (including Engrailed in embryos lacking maternal and zygotic srt, and Senseless and Achaete in wing discs) are reduced. Activation of Wg targets in the receiving cells does not require srt. Hence, the function of Srt is restricted to events occurring within the Wg-producing cells. We show that srt is not required for any aspect of Hedgehog (Hh) signal transduction, suggesting specificity of srt for the Wg pathway. We propose that srt encodes a protein required for Wg secretion that regulates maturation, membrane targeting or delivery of Wg. Loss of srt function in turn diminishes Wg-pathway activation in receiving cells.

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Published In

Development (Cambridge, England)

DOI

EISSN

1477-9129

ISSN

0950-1991

Publication Date

December 2006

Volume

133

Issue

24

Start / End Page

4901 / 4911

Related Subject Headings

  • Wnt1 Protein
  • Wnt Proteins
  • Wings, Animal
  • Signal Transduction
  • Sequence Alignment
  • Proto-Oncogene Proteins
  • Protein Transport
  • Molecular Sequence Data
  • Membrane Proteins
  • Male
 

Citation

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Goodman, R. M., Thombre, S., Firtina, Z., Gray, D., Betts, D., Roebuck, J., … Selva, E. M. (2006). Sprinter: a novel transmembrane protein required for Wg secretion and signaling. Development (Cambridge, England), 133(24), 4901–4911. https://doi.org/10.1242/dev.02674
Goodman, Robyn M., Shreya Thombre, Zeynep Firtina, Dione Gray, Daniella Betts, Jamie Roebuck, Eric P. Spana, and Erica M. Selva. “Sprinter: a novel transmembrane protein required for Wg secretion and signaling.Development (Cambridge, England) 133, no. 24 (December 2006): 4901–11. https://doi.org/10.1242/dev.02674.
Goodman RM, Thombre S, Firtina Z, Gray D, Betts D, Roebuck J, et al. Sprinter: a novel transmembrane protein required for Wg secretion and signaling. Development (Cambridge, England). 2006 Dec;133(24):4901–11.
Goodman, Robyn M., et al. “Sprinter: a novel transmembrane protein required for Wg secretion and signaling.Development (Cambridge, England), vol. 133, no. 24, Dec. 2006, pp. 4901–11. Epmc, doi:10.1242/dev.02674.
Goodman RM, Thombre S, Firtina Z, Gray D, Betts D, Roebuck J, Spana EP, Selva EM. Sprinter: a novel transmembrane protein required for Wg secretion and signaling. Development (Cambridge, England). 2006 Dec;133(24):4901–4911.
Journal cover image

Published In

Development (Cambridge, England)

DOI

EISSN

1477-9129

ISSN

0950-1991

Publication Date

December 2006

Volume

133

Issue

24

Start / End Page

4901 / 4911

Related Subject Headings

  • Wnt1 Protein
  • Wnt Proteins
  • Wings, Animal
  • Signal Transduction
  • Sequence Alignment
  • Proto-Oncogene Proteins
  • Protein Transport
  • Molecular Sequence Data
  • Membrane Proteins
  • Male