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Translocation of Y-linked genes to the dot chromosome in Drosophila pseudoobscura.

Publication ,  Journal Article
Larracuente, AM; Noor, MAF; Clark, AG
Published in: Molecular biology and evolution
July 2010

One of the most striking cases of sex chromosome reorganization in Drosophila occurred in the lineage ancestral to Drosophila pseudoobscura, where there was a translocation of Y-linked genes to an autosome. These genes went from being present only in males, never recombining, and having an effective population size of 0.5N to a state of autosomal linkage, where they are passed through both sexes, may recombine, and their effective population size has quadrupled. These genes appear to be functional, and they underwent a drastic reduction in intron size after the translocation. A Y-autosome translocation may pose problems in meiosis if the rDNA locus responsible for X-Y pairing had also moved to an autosome. In this study, we demonstrate that the Y-autosome translocation moved Y-linked genes onto the dot chromosome, a small, mainly heterochromatic autosome with some sex chromosome-like properties. The rDNA repeats occur exclusively on the X chromosome in D. pseudoobscura, but we found that the new Y chromosome of this species harbors four clusters bearing only the intergenic spacer region (IGS) of the rDNA repeats. This arrangement appears analogous to the situation in Drosophila simulans, where X-rDNA to Y-IGS pairing could be responsible for X-Y chromosome pairing. We postulate that the nascent D. pseudoobscura Y chromosome acquired and amplified copies of the IGS, suggesting a potential mechanism for X-Y pairing in D. pseudoobscura.

Duke Scholars

Published In

Molecular biology and evolution

DOI

ISSN

1537-1719

Publication Date

July 2010

Volume

27

Issue

7

Start / End Page

1612 / 1620

Related Subject Headings

  • Y Chromosome
  • X Chromosome
  • Translocation, Genetic
  • Repetitive Sequences, Nucleic Acid
  • Male
  • Introns
  • Genes, Insect
  • Female
  • Evolutionary Biology
  • Drosophila
 

Citation

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Larracuente, A. M., Noor, M. A. F., & Clark, A. G. (2010). Translocation of Y-linked genes to the dot chromosome in Drosophila pseudoobscura. Molecular Biology and Evolution, 27(7), 1612–1620. https://doi.org/10.1093/molbev/msq045
Larracuente, A. M., M. A. F. Noor, and A. G. Clark. “Translocation of Y-linked genes to the dot chromosome in Drosophila pseudoobscura.Molecular Biology and Evolution 27, no. 7 (July 2010): 1612–20. https://doi.org/10.1093/molbev/msq045.
Larracuente AM, Noor MAF, Clark AG. Translocation of Y-linked genes to the dot chromosome in Drosophila pseudoobscura. Molecular biology and evolution. 2010 Jul;27(7):1612–20.
Larracuente, A. M., et al. “Translocation of Y-linked genes to the dot chromosome in Drosophila pseudoobscura.Molecular Biology and Evolution, vol. 27, no. 7, July 2010, pp. 1612–20. Manual, doi:10.1093/molbev/msq045.
Larracuente AM, Noor MAF, Clark AG. Translocation of Y-linked genes to the dot chromosome in Drosophila pseudoobscura. Molecular biology and evolution. 2010 Jul;27(7):1612–1620.
Journal cover image

Published In

Molecular biology and evolution

DOI

ISSN

1537-1719

Publication Date

July 2010

Volume

27

Issue

7

Start / End Page

1612 / 1620

Related Subject Headings

  • Y Chromosome
  • X Chromosome
  • Translocation, Genetic
  • Repetitive Sequences, Nucleic Acid
  • Male
  • Introns
  • Genes, Insect
  • Female
  • Evolutionary Biology
  • Drosophila