Skip to main content
Journal cover image

Dependence of paracentric inversion rate on tract length.

Publication ,  Journal Article
York, TL; Durrett, R; Nielsen, R
Published in: BMC bioinformatics
April 2007

We develop a Bayesian method based on MCMC for estimating the relative rates of pericentric and paracentric inversions from marker data from two species. The method also allows estimation of the distribution of inversion tract lengths.We apply the method to data from Drosophila melanogaster and D. yakuba. We find that pericentric inversions occur at a much lower rate compared to paracentric inversions. The average paracentric inversion tract length is approx. 4.8 Mb with small inversions being more frequent than large inversions. If the two breakpoints defining a paracentric inversion tract are uniformly and independently distributed over chromosome arms there will be more short tract-length inversions than long; we find an even greater preponderance of short tract lengths than this would predict. Thus there appears to be a correlation between the positions of breakpoints which favors shorter tract lengths.The method developed in this paper provides the first statistical estimator for estimating the distribution of inversion tract lengths from marker data. Application of this method for a number of data sets may help elucidate the relationship between the length of an inversion and the chance that it will get accepted.

Duke Scholars

Published In

BMC bioinformatics

DOI

EISSN

1471-2105

ISSN

1471-2105

Publication Date

April 2007

Volume

8

Start / End Page

115

Related Subject Headings

  • Introns
  • Genetic Markers
  • Gene Frequency
  • Drosophila
  • Chromosome Mapping
  • Chromosome Inversion
  • Bioinformatics
  • Animals
  • 49 Mathematical sciences
  • 46 Information and computing sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
York, T. L., Durrett, R., & Nielsen, R. (2007). Dependence of paracentric inversion rate on tract length. BMC Bioinformatics, 8, 115. https://doi.org/10.1186/1471-2105-8-115
York, Thomas L., Rick Durrett, and Rasmus Nielsen. “Dependence of paracentric inversion rate on tract length.BMC Bioinformatics 8 (April 2007): 115. https://doi.org/10.1186/1471-2105-8-115.
York TL, Durrett R, Nielsen R. Dependence of paracentric inversion rate on tract length. BMC bioinformatics. 2007 Apr;8:115.
York, Thomas L., et al. “Dependence of paracentric inversion rate on tract length.BMC Bioinformatics, vol. 8, Apr. 2007, p. 115. Epmc, doi:10.1186/1471-2105-8-115.
York TL, Durrett R, Nielsen R. Dependence of paracentric inversion rate on tract length. BMC bioinformatics. 2007 Apr;8:115.
Journal cover image

Published In

BMC bioinformatics

DOI

EISSN

1471-2105

ISSN

1471-2105

Publication Date

April 2007

Volume

8

Start / End Page

115

Related Subject Headings

  • Introns
  • Genetic Markers
  • Gene Frequency
  • Drosophila
  • Chromosome Mapping
  • Chromosome Inversion
  • Bioinformatics
  • Animals
  • 49 Mathematical sciences
  • 46 Information and computing sciences