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Nerve-sparing focal cryoablation of prostate cancer.

Publication ,  Journal Article
Polascik, TJ; Mayes, JM; Mouraviev, V
Published in: Curr Opin Urol
March 2009

PURPOSE OF REVIEW: We evaluate the rationale, candidate selection, and results of the first clinical studies of focal cryoablation for select patients with low volume and low-to-low - moderate risk features of prostate cancer as a possible alternative to whole gland treatment. RECENT FINDINGS: For a select cohort of patients with low-to-low - moderate risk unifocal or unilateral prostate cancer, a number of ablative treatment options for focal therapy are available with cryotherapy having the most clinical experience. However, retrospective pathological data from large prostatectomy series do not clearly reveal valid and reproducible criteria to select appropriate candidates for focal cryoablation due to the complexity of tumorigenesis in early stage disease. SUMMARY: The concept of focal therapy is evolving with the understanding of the biologic variability (clinically aggressive, significant, or insignificant) of prostate cancers that may require different treatment approaches. Minimally-invasive, parenchyma-preserving cryoablation can be considered as a potential feasible option in the treatment armamentarium of early stage, localized prostate cancer in appropriately selected candidates.

Duke Scholars

Published In

Curr Opin Urol

DOI

EISSN

1473-6586

Publication Date

March 2009

Volume

19

Issue

2

Start / End Page

182 / 187

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Prostate
  • Patient Selection
  • Minimally Invasive Surgical Procedures
  • Male
  • Humans
  • Cryosurgery
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
 

Citation

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Polascik, T. J., Mayes, J. M., & Mouraviev, V. (2009). Nerve-sparing focal cryoablation of prostate cancer. Curr Opin Urol, 19(2), 182–187. https://doi.org/10.1097/MOU.0b013e328323f603
Polascik, Thomas J., Janice M. Mayes, and Vladimir Mouraviev. “Nerve-sparing focal cryoablation of prostate cancer.Curr Opin Urol 19, no. 2 (March 2009): 182–87. https://doi.org/10.1097/MOU.0b013e328323f603.
Polascik TJ, Mayes JM, Mouraviev V. Nerve-sparing focal cryoablation of prostate cancer. Curr Opin Urol. 2009 Mar;19(2):182–7.
Polascik, Thomas J., et al. “Nerve-sparing focal cryoablation of prostate cancer.Curr Opin Urol, vol. 19, no. 2, Mar. 2009, pp. 182–87. Pubmed, doi:10.1097/MOU.0b013e328323f603.
Polascik TJ, Mayes JM, Mouraviev V. Nerve-sparing focal cryoablation of prostate cancer. Curr Opin Urol. 2009 Mar;19(2):182–187.

Published In

Curr Opin Urol

DOI

EISSN

1473-6586

Publication Date

March 2009

Volume

19

Issue

2

Start / End Page

182 / 187

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Prostate
  • Patient Selection
  • Minimally Invasive Surgical Procedures
  • Male
  • Humans
  • Cryosurgery
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services