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Implantable cardioverter defibrillator in high-risk long QT syndrome patients.

Publication ,  Journal Article
Zareba, W; Moss, AJ; Daubert, JP; Hall, WJ; Robinson, JL; Andrews, M
Published in: J Cardiovasc Electrophysiol
April 2003

INTRODUCTION: Implantable cardioverter defibrillators (ICDs) are increasingly being used in high-risk long QT syndrome (LQTS) patients, but there are limited data regarding clinical experience with this therapeutic modality. The aim of this study is to describe the clinical characteristics of 125 LQTS patients treated with ICDs compared with LQTS patients having similar risk indications who were not treated with ICDs. Among 125 LQTS patients with ICDs, there were 54 cardiac arrest survivors, 19 patients who had ICDs implanted due to recurrent syncope despite beta-blocker therapy, and 52 patients with ICDs implanted due to other reasons, including syncope and LQTS-related sudden death in a close family member. Patients with cardiac arrest and those with recurrent syncope despite beta-blocker therapy (n = 73) were compared to 161 LQTS patients who had similar indications (89 cardiac arrest and 72 recurrent syncope despite beta-blocker therapy) but did not receive ICDs. Total mortality was the endpoint of the analysis. There was 1 (1.3%) death in 73 ICD patients followed an average of 3 years, whereas there were 26 deaths (16%) in non-ICD patients during mean 8-year follow-up (P = 0.07 from log rank test from Kaplan-Meier curves). CONCLUSION: ICDs provide an important therapeutic option to prevent sudden arrhythmic death in high-risk LQTS patients. A long-term prospective study is needed to determine the benefit of this therapeutic modality in LQTS patients.

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Published In

J Cardiovasc Electrophysiol

DOI

ISSN

1045-3873

Publication Date

April 2003

Volume

14

Issue

4

Start / End Page

337 / 341

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Syncope
  • Risk Factors
  • Retrospective Studies
  • Male
  • Long QT Syndrome
  • Humans
  • Heart Arrest
  • Follow-Up Studies
  • Female
 

Citation

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Zareba, W., Moss, A. J., Daubert, J. P., Hall, W. J., Robinson, J. L., & Andrews, M. (2003). Implantable cardioverter defibrillator in high-risk long QT syndrome patients. J Cardiovasc Electrophysiol, 14(4), 337–341. https://doi.org/10.1046/j.1540-8167.2003.02545.x
Zareba, Wojciech, Arthur J. Moss, James P. Daubert, W Jackson Hall, Jennifer L. Robinson, and Mark Andrews. “Implantable cardioverter defibrillator in high-risk long QT syndrome patients.J Cardiovasc Electrophysiol 14, no. 4 (April 2003): 337–41. https://doi.org/10.1046/j.1540-8167.2003.02545.x.
Zareba W, Moss AJ, Daubert JP, Hall WJ, Robinson JL, Andrews M. Implantable cardioverter defibrillator in high-risk long QT syndrome patients. J Cardiovasc Electrophysiol. 2003 Apr;14(4):337–41.
Zareba, Wojciech, et al. “Implantable cardioverter defibrillator in high-risk long QT syndrome patients.J Cardiovasc Electrophysiol, vol. 14, no. 4, Apr. 2003, pp. 337–41. Pubmed, doi:10.1046/j.1540-8167.2003.02545.x.
Zareba W, Moss AJ, Daubert JP, Hall WJ, Robinson JL, Andrews M. Implantable cardioverter defibrillator in high-risk long QT syndrome patients. J Cardiovasc Electrophysiol. 2003 Apr;14(4):337–341.
Journal cover image

Published In

J Cardiovasc Electrophysiol

DOI

ISSN

1045-3873

Publication Date

April 2003

Volume

14

Issue

4

Start / End Page

337 / 341

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Syncope
  • Risk Factors
  • Retrospective Studies
  • Male
  • Long QT Syndrome
  • Humans
  • Heart Arrest
  • Follow-Up Studies
  • Female