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The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes.

Publication ,  Journal Article
Zhang, N; He, Y-W
Published in: J Immunol
June 1, 2005

The antiapoptotic protein Bcl-x(L) is induced in activated T lymphocytes upon costimulation through CD28, 4-1BB, and OX40. Bcl-x(L) is also highly enriched in memory T lymphocytes. Based on this body of evidence, it was thought that Bcl-x(L) plays an essential role in the generation of effector and memory T lymphocytes. We report that mice with a conditional deletion of Bcl-x in T lymphocytes develop a normal CD8(+) T cell response to Listeria monocytogenes infection. Furthermore, Bcl-x conditional knockout mice exhibit normal T-dependent humoral immune responses. These results indicate that Bcl-x is dispensable for the generation of effector and memory T lymphocytes and suggest that costimulation of T lymphocytes promotes their survival through a Bcl-x(L) independent mechanism.

Duke Scholars

Published In

J Immunol

DOI

ISSN

0022-1767

Publication Date

June 1, 2005

Volume

174

Issue

11

Start / End Page

6967 / 6973

Location

United States

Related Subject Headings

  • bcl-X Protein
  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocytes, Cytotoxic
  • T-Lymphocyte Subsets
  • Proto-Oncogene Proteins c-bcl-2
  • Mice, Transgenic
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, N., & He, Y.-W. (2005). The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes. J Immunol, 174(11), 6967–6973. https://doi.org/10.4049/jimmunol.174.11.6967
Zhang, Nu, and You-Wen He. “The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes.J Immunol 174, no. 11 (June 1, 2005): 6967–73. https://doi.org/10.4049/jimmunol.174.11.6967.
Zhang, Nu, and You-Wen He. “The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes.J Immunol, vol. 174, no. 11, June 2005, pp. 6967–73. Pubmed, doi:10.4049/jimmunol.174.11.6967.

Published In

J Immunol

DOI

ISSN

0022-1767

Publication Date

June 1, 2005

Volume

174

Issue

11

Start / End Page

6967 / 6973

Location

United States

Related Subject Headings

  • bcl-X Protein
  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocytes, Cytotoxic
  • T-Lymphocyte Subsets
  • Proto-Oncogene Proteins c-bcl-2
  • Mice, Transgenic
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male