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The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment.

Publication ,  Journal Article
Jia, W; Li, H; He, Y-W
Published in: Blood
December 1, 2005

Leukocyte recruitment to inflammation sites depends on interactions between integrins and extracellular matrix (ECM). In this report we show that mice lacking the ECM protein mindin exhibit severely impaired recruitment of neutrophils and macrophages in 4 different inflammation models. Furthermore, neutrophils directly bind to immobilized mindin, and mindin matrix mediates neutrophil migration in vitro. The adhesion of neutrophils to mindin is blocked by anti-integrin alpha4, anti-integrin alpha(M), and anti-integrin beta2 antibodies. We also show that HEK-293 cells transfected with cDNA encoding these integrins exhibit enhanced binding to immobilized mindin matrix and the increased binding can be blocked by anti-integrin antibodies. Our results suggest that mindin serves as a novel ligand for integrins and mindin-integrin interactions are critical for inflammatory cell recruitment in vivo.

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Published In

Blood

DOI

ISSN

0006-4971

Publication Date

December 1, 2005

Volume

106

Issue

12

Start / End Page

3854 / 3859

Location

United States

Related Subject Headings

  • Neutrophils
  • Neutrophil Infiltration
  • Mice, Mutant Strains
  • Mice
  • Macrophages
  • Ligands
  • Integrins
  • Inflammation
  • Immunology
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Jia, W., Li, H., & He, Y.-W. (2005). The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment. Blood, 106(12), 3854–3859. https://doi.org/10.1182/blood-2005-04-1658
Jia, Wei, Hong Li, and You-Wen He. “The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment.Blood 106, no. 12 (December 1, 2005): 3854–59. https://doi.org/10.1182/blood-2005-04-1658.
Jia, Wei, et al. “The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment.Blood, vol. 106, no. 12, Dec. 2005, pp. 3854–59. Pubmed, doi:10.1182/blood-2005-04-1658.

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

December 1, 2005

Volume

106

Issue

12

Start / End Page

3854 / 3859

Location

United States

Related Subject Headings

  • Neutrophils
  • Neutrophil Infiltration
  • Mice, Mutant Strains
  • Mice
  • Macrophages
  • Ligands
  • Integrins
  • Inflammation
  • Immunology
  • Humans