Expression of cell-adhesion molecules in the salivary gland microenvironment of Sjögren's syndrome.
OBJECTIVE: The potential role of cell adhesion molecules in the pathogenesis of Sjögren's syndrome (SS) was assessed by examining their expression in salivary gland (SGL) tissue. METHODS: Intercellular adhesion molecule type 1 (ICAM-1), lymphocyte function-associated antigen type 1 (LFA-1), LFA-3, CD2, and CD44 expression were determined using indirect immunofluorescence techniques. RESULTS: In inflamed labial SGL tissue, ICAM-1 expression was evident on infiltrating LFA-1+/CD2+/LFA-3+ mononuclear cells, and to a limited extent on SGL acinar epithelial cells adjacent to sites of intense inflammation. CONCLUSION: In SS, the SGL microenvironment is characterized by only a modest up-regulation of ICAM-1 expression on epithelial cells, despite the presence of T cells bearing an activated phenotype.
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Related Subject Headings
- Up-Regulation
- Sjogren's Syndrome
- Salivary Glands
- Receptors, Lymphocyte Homing
- Receptors, Immunologic
- Middle Aged
- Membrane Glycoproteins
- Male
- Lymphocyte Function-Associated Antigen-1
- Intercellular Adhesion Molecule-1
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Up-Regulation
- Sjogren's Syndrome
- Salivary Glands
- Receptors, Lymphocyte Homing
- Receptors, Immunologic
- Middle Aged
- Membrane Glycoproteins
- Male
- Lymphocyte Function-Associated Antigen-1
- Intercellular Adhesion Molecule-1