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Mechanics of T cell receptor gene rearrangement.

Publication ,  Journal Article
Krangel, MS
Published in: Curr Opin Immunol
April 2009

The four T cell receptor genes (Tcra, Tcrb, Tcrg, Tcrd) are assembled by V(D)J recombination according to distinct programs during intrathymic T cell development. These programs depend on genetic factors, including gene segment order and recombination signal sequences. They also depend on epigenetic factors. Regulated changes in chromatin structure, directed by enhancers and promoter, can modify the availability of recombination signal sequences to the RAG recombinase. Regulated changes in locus conformation may control the synapsis of distant recombination signal sequences, and regulated changes in subnuclear positioning may influence locus recombination events by unknown mechanisms. Together these influences may explain the ordered activation and inactivation of T cell receptor locus recombination events and the phenomenon of Tcrb allelic exclusion.

Duke Scholars

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Published In

Curr Opin Immunol

DOI

EISSN

1879-0372

Publication Date

April 2009

Volume

21

Issue

2

Start / End Page

133 / 139

Location

England

Related Subject Headings

  • VDJ Recombinases
  • VDJ Exons
  • Signal Transduction
  • Recombination, Genetic
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, Antigen, T-Cell, alpha-beta
  • Immunology
  • Humans
  • Gene Rearrangement, T-Lymphocyte
  • Animals
 

Citation

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Krangel, M. S. (2009). Mechanics of T cell receptor gene rearrangement. Curr Opin Immunol, 21(2), 133–139. https://doi.org/10.1016/j.coi.2009.03.009
Krangel, Michael S. “Mechanics of T cell receptor gene rearrangement.Curr Opin Immunol 21, no. 2 (April 2009): 133–39. https://doi.org/10.1016/j.coi.2009.03.009.
Krangel MS. Mechanics of T cell receptor gene rearrangement. Curr Opin Immunol. 2009 Apr;21(2):133–9.
Krangel, Michael S. “Mechanics of T cell receptor gene rearrangement.Curr Opin Immunol, vol. 21, no. 2, Apr. 2009, pp. 133–39. Pubmed, doi:10.1016/j.coi.2009.03.009.
Krangel MS. Mechanics of T cell receptor gene rearrangement. Curr Opin Immunol. 2009 Apr;21(2):133–139.
Journal cover image

Published In

Curr Opin Immunol

DOI

EISSN

1879-0372

Publication Date

April 2009

Volume

21

Issue

2

Start / End Page

133 / 139

Location

England

Related Subject Headings

  • VDJ Recombinases
  • VDJ Exons
  • Signal Transduction
  • Recombination, Genetic
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, Antigen, T-Cell, alpha-beta
  • Immunology
  • Humans
  • Gene Rearrangement, T-Lymphocyte
  • Animals