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A computationally advantageous system for fitting probabilistic decompression models to empirical data.

Publication ,  Journal Article
Howle, LE; Weber, PW; Vann, RD
Published in: Computers in biology and medicine
December 2009

To investigate the nature and mechanisms of decompression sickness (DCS), we developed a system for evaluating the success of decompression models in predicting DCS probability from empirical data. Model parameters were estimated using maximum likelihood techniques. Exact integrals of risk functions and tissue kinetics transition times were derived. Agreement with previously published results was excellent including: (a) maximum likelihood values within one log-likelihood unit of previous results and improvements by re-optimization; (b) mean predicted DCS incidents within 1.4% of observed DCS; and (c) time of DCS occurrence prediction. Alternative optimization and homogeneous parallel processing techniques yielded faster model optimization times.

Duke Scholars

Published In

Computers in biology and medicine

DOI

EISSN

1879-0534

ISSN

0010-4825

Publication Date

December 2009

Volume

39

Issue

12

Start / End Page

1117 / 1129

Related Subject Headings

  • Time Factors
  • Pressure
  • Models, Statistical
  • Models, Biological
  • Linear Models
  • Likelihood Functions
  • Humans
  • Diving
  • Decompression Sickness
  • Data Interpretation, Statistical
 

Citation

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ICMJE
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Howle, L. E., Weber, P. W., & Vann, R. D. (2009). A computationally advantageous system for fitting probabilistic decompression models to empirical data. Computers in Biology and Medicine, 39(12), 1117–1129. https://doi.org/10.1016/j.compbiomed.2009.09.006
Howle, Laurens E., Paul W. Weber, and Richard D. Vann. “A computationally advantageous system for fitting probabilistic decompression models to empirical data.Computers in Biology and Medicine 39, no. 12 (December 2009): 1117–29. https://doi.org/10.1016/j.compbiomed.2009.09.006.
Howle LE, Weber PW, Vann RD. A computationally advantageous system for fitting probabilistic decompression models to empirical data. Computers in biology and medicine. 2009 Dec;39(12):1117–29.
Howle, Laurens E., et al. “A computationally advantageous system for fitting probabilistic decompression models to empirical data.Computers in Biology and Medicine, vol. 39, no. 12, Dec. 2009, pp. 1117–29. Epmc, doi:10.1016/j.compbiomed.2009.09.006.
Howle LE, Weber PW, Vann RD. A computationally advantageous system for fitting probabilistic decompression models to empirical data. Computers in biology and medicine. 2009 Dec;39(12):1117–1129.
Journal cover image

Published In

Computers in biology and medicine

DOI

EISSN

1879-0534

ISSN

0010-4825

Publication Date

December 2009

Volume

39

Issue

12

Start / End Page

1117 / 1129

Related Subject Headings

  • Time Factors
  • Pressure
  • Models, Statistical
  • Models, Biological
  • Linear Models
  • Likelihood Functions
  • Humans
  • Diving
  • Decompression Sickness
  • Data Interpretation, Statistical