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Methylphenidate effects on functional outcomes in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).

Publication ,  Journal Article
Abikoff, HB; Vitiello, B; Riddle, MA; Cunningham, C; Greenhill, LL; Swanson, JM; Chuang, SZ; Davies, M; Kastelic, E; Wigal, SB; Evans, L ...
Published in: J Child Adolesc Psychopharmacol
October 2007

OBJECTIVE: The purpose of this study was to examine the effects of methylphenidate (MPH) on functional outcomes, including children's social skills, classroom behavior, emotional status, and parenting stress, during the 4-week, double-blind placebo controlled phase of the Preschoolers with Attention Deficit/Hyperactivity Disorder (ADHD) Treatment Study (PATS). METHODS: A total of 114 preschoolers who had improved with acute MPH treatment, were randomized to their best MPH dose (M = 14.22 mg/day; n = 63) or placebo (PL; n = 51). Assessments included the Clinical Global Impression-Severity (CGI-S), parent and teacher versions of the Strengths and Weaknesses of ADHD-Symptoms and Normal Behaviors (SWAN), Social Competence Scale (SCS), Social Skills Rating System (SSRS), and Early Childhood Inventory (ECI), and Parenting Stress Index (PSI). RESULTS: Medication effects varied by informant and outcome measure. Parent measures and teacher SWAN scores did not differentially improve with MPH. Parent-rated depression (p < 0.02) and dysthymia (p < 0.001) on the ECI worsened with MPH, but scores were not in the clinical range. Significant medication effects were found on clinician CGI-S (p < 0.0001) and teacher social competence ratings (SCS, p < 0.03). CONCLUSIONS: Preschoolers with ADHD treated with MPH for 4 weeks improve in some aspects of functioning. Additional improvements might require longer treatment, higher doses, and/or intensive behavioral treatment in combination with medication.

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Published In

J Child Adolesc Psychopharmacol

DOI

ISSN

1044-5463

Publication Date

October 2007

Volume

17

Issue

5

Start / End Page

581 / 592

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Stress, Psychological
  • Social Behavior
  • Schools
  • Parents
  • Methylphenidate
  • Male
  • Humans
  • Female
  • Emotions
 

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Abikoff, H. B., Vitiello, B., Riddle, M. A., Cunningham, C., Greenhill, L. L., Swanson, J. M., … Wigal, T. (2007). Methylphenidate effects on functional outcomes in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS). J Child Adolesc Psychopharmacol, 17(5), 581–592. https://doi.org/10.1089/cap.2007.0068
Abikoff, Howard B., Benedetto Vitiello, Mark A. Riddle, Charles Cunningham, Laurence L. Greenhill, James M. Swanson, Shirley Z. Chuang, et al. “Methylphenidate effects on functional outcomes in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).J Child Adolesc Psychopharmacol 17, no. 5 (October 2007): 581–92. https://doi.org/10.1089/cap.2007.0068.
Abikoff HB, Vitiello B, Riddle MA, Cunningham C, Greenhill LL, Swanson JM, et al. Methylphenidate effects on functional outcomes in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS). J Child Adolesc Psychopharmacol. 2007 Oct;17(5):581–92.
Abikoff, Howard B., et al. “Methylphenidate effects on functional outcomes in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).J Child Adolesc Psychopharmacol, vol. 17, no. 5, Oct. 2007, pp. 581–92. Pubmed, doi:10.1089/cap.2007.0068.
Abikoff HB, Vitiello B, Riddle MA, Cunningham C, Greenhill LL, Swanson JM, Chuang SZ, Davies M, Kastelic E, Wigal SB, Evans L, Ghuman JK, Kollins SH, McCracken JT, McGough JJ, Murray DW, Posner K, Skrobala AM, Wigal T. Methylphenidate effects on functional outcomes in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS). J Child Adolesc Psychopharmacol. 2007 Oct;17(5):581–592.
Journal cover image

Published In

J Child Adolesc Psychopharmacol

DOI

ISSN

1044-5463

Publication Date

October 2007

Volume

17

Issue

5

Start / End Page

581 / 592

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Stress, Psychological
  • Social Behavior
  • Schools
  • Parents
  • Methylphenidate
  • Male
  • Humans
  • Female
  • Emotions