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Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection.

Publication ,  Journal Article
Sun, Y; Permar, SR; Buzby, AP; Letvin, NL
Published in: J Virol
August 2007

It has long been appreciated that CD4+ T lymphocytes are dysfunctional in human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV)-infected individuals, and it has recently been shown that HIV/SIV infections are associated with a dramatic early destruction of memory CD4+ T lymphocytes. However, the relative contributions of CD4+ T-lymphocyte dysfunction and loss to immune dysregulation during primary HIV/SIV infection have not been fully elucidated. In the current study, we evaluated CD4+ T lymphocytes and their functional repertoire during primary SIVmac251 infection in rhesus monkeys. We show that the extent of loss of memory CD4+ T lymphocytes and staphylococcal enterotoxin B-stimulated cytokine production by total CD4+ T lymphocytes during primary SIVmac251 infection is tightly linked in a cohort of six rhesus monkeys to set point plasma viral RNA levels, with greater loss and dysfunction being associated with higher steady-state viral replication. Moreover, in exploring the mechanism underlying this phenomenon, we demonstrate that the loss of functional CD4+ T lymphocytes during primary SIVmac251 infection is associated with both a selective depletion of memory CD4+ T cells and a loss of the functional capacity of the memory CD4+ T lymphocytes that escape viral destruction.

Duke Scholars

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

August 2007

Volume

81

Issue

15

Start / End Page

8009 / 8015

Location

United States

Related Subject Headings

  • Virology
  • T-Lymphocyte Subsets
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • RNA, Viral
  • Macaca mulatta
  • Immunologic Memory
  • Humans
  • HIV
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sun, Y., Permar, S. R., Buzby, A. P., & Letvin, N. L. (2007). Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection. J Virol, 81(15), 8009–8015. https://doi.org/10.1128/JVI.00482-07
Sun, Yue, Sallie R. Permar, Adam P. Buzby, and Norman L. Letvin. “Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection.J Virol 81, no. 15 (August 2007): 8009–15. https://doi.org/10.1128/JVI.00482-07.
Sun Y, Permar SR, Buzby AP, Letvin NL. Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection. J Virol. 2007 Aug;81(15):8009–15.
Sun, Yue, et al. “Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection.J Virol, vol. 81, no. 15, Aug. 2007, pp. 8009–15. Pubmed, doi:10.1128/JVI.00482-07.
Sun Y, Permar SR, Buzby AP, Letvin NL. Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection. J Virol. 2007 Aug;81(15):8009–8015.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

August 2007

Volume

81

Issue

15

Start / End Page

8009 / 8015

Location

United States

Related Subject Headings

  • Virology
  • T-Lymphocyte Subsets
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • RNA, Viral
  • Macaca mulatta
  • Immunologic Memory
  • Humans
  • HIV