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Towards a field-compatible optical spectroscopic device for cervical cancer screening in resource-limited settings: effects of calibration and pressure.

Publication ,  Journal Article
Chang, VT-C; Merisier, D; Yu, B; Walmer, DK; Ramanujam, N
Published in: Optics express
September 2011

Quantitative optical spectroscopy has the potential to provide an effective low cost, and portable solution for cervical pre-cancer screening in resource-limited communities. However, clinical studies to validate the use of this technology in resource-limited settings require low power consumption and good quality control that is minimally influenced by the operator or variable environmental conditions in the field. The goal of this study was to evaluate the effects of two sources of potential error: calibration and pressure on the extraction of absorption and scattering properties of normal cervical tissues in a resource-limited setting in Leogane, Haiti. Our results show that self-calibrated measurements improved scattering measurements through real-time correction of system drift, in addition to minimizing the time required for post-calibration. Variations in pressure (tested without the potential confounding effects of calibration error) caused local changes in vasculature and scatterer density that significantly impacted the tissue absorption and scattering properties Future spectroscopic systems intended for clinical use, particularly where operator training is not viable and environmental conditions unpredictable, should incorporate a real-time self-calibration channel and collect diffuse reflectance spectra at a consistent pressure to maximize data integrity.

Duke Scholars

Published In

Optics express

DOI

EISSN

1094-4087

ISSN

1094-4087

Publication Date

September 2011

Volume

19

Issue

19

Start / End Page

17908 / 17924

Related Subject Headings

  • Vaginal Smears
  • Uterine Cervical Neoplasms
  • Spectrum Analysis
  • Sensitivity and Specificity
  • Pressure
  • Phantoms, Imaging
  • Optics
  • Optical Devices
  • Monte Carlo Method
  • Middle Aged
 

Citation

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ICMJE
MLA
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Chang, V.-C., Merisier, D., Yu, B., Walmer, D. K., & Ramanujam, N. (2011). Towards a field-compatible optical spectroscopic device for cervical cancer screening in resource-limited settings: effects of calibration and pressure. Optics Express, 19(19), 17908–17924. https://doi.org/10.1364/oe.19.017908
Chang, Vivide Tuan-Chyan, Delson Merisier, Bing Yu, David K. Walmer, and Nirmala Ramanujam. “Towards a field-compatible optical spectroscopic device for cervical cancer screening in resource-limited settings: effects of calibration and pressure.Optics Express 19, no. 19 (September 2011): 17908–24. https://doi.org/10.1364/oe.19.017908.
Chang, Vivide Tuan-Chyan, et al. “Towards a field-compatible optical spectroscopic device for cervical cancer screening in resource-limited settings: effects of calibration and pressure.Optics Express, vol. 19, no. 19, Sept. 2011, pp. 17908–24. Epmc, doi:10.1364/oe.19.017908.
Journal cover image

Published In

Optics express

DOI

EISSN

1094-4087

ISSN

1094-4087

Publication Date

September 2011

Volume

19

Issue

19

Start / End Page

17908 / 17924

Related Subject Headings

  • Vaginal Smears
  • Uterine Cervical Neoplasms
  • Spectrum Analysis
  • Sensitivity and Specificity
  • Pressure
  • Phantoms, Imaging
  • Optics
  • Optical Devices
  • Monte Carlo Method
  • Middle Aged