Skip to main content
Journal cover image

Imaging for assessment of radiation-induced normal tissue effects.

Publication ,  Journal Article
Jeraj, R; Cao, Y; Ten Haken, RK; Hahn, C; Marks, L
Published in: Int J Radiat Oncol Biol Phys
March 1, 2010

Imaging can provide quantitative assessment of radiation-induced normal tissue effects. Identifying an early sign of normal tissue damage with imaging would have the potential to predict organ dysfunction, thereby allowing reoptimization of treatment strategies based on individual patients' risks and benefits. Early detection with noninvasive imaging may enable interventions to mitigate therapy-associated injury before its clinical manifestation. Furthermore, successive imaging may provide an objective assessment of the impact of such mitigation therapies. However, many problems make application of imaging to normal tissue assessment challenging, and further work is required to establish imaging biomarkers as surrogate endpoints of clinical outcome. The performance of clinical trials in which normal tissue injury is a clearly defined endpoint would greatly aid in realization of these goals.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

March 1, 2010

Volume

76

Issue

3 Suppl

Start / End Page

S140 / S144

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed, Single-Photon
  • Radiation Injuries
  • Positron-Emission Tomography
  • Oncology & Carcinogenesis
  • Magnetic Resonance Imaging
  • Humans
  • Diagnostic Imaging
  • Biomarkers
  • 5105 Medical and biological physics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jeraj, R., Cao, Y., Ten Haken, R. K., Hahn, C., & Marks, L. (2010). Imaging for assessment of radiation-induced normal tissue effects. Int J Radiat Oncol Biol Phys, 76(3 Suppl), S140–S144. https://doi.org/10.1016/j.ijrobp.2009.08.077
Jeraj, Robert, Yue Cao, Randall K. Ten Haken, Carol Hahn, and Lawrence Marks. “Imaging for assessment of radiation-induced normal tissue effects.Int J Radiat Oncol Biol Phys 76, no. 3 Suppl (March 1, 2010): S140–44. https://doi.org/10.1016/j.ijrobp.2009.08.077.
Jeraj R, Cao Y, Ten Haken RK, Hahn C, Marks L. Imaging for assessment of radiation-induced normal tissue effects. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S140–4.
Jeraj, Robert, et al. “Imaging for assessment of radiation-induced normal tissue effects.Int J Radiat Oncol Biol Phys, vol. 76, no. 3 Suppl, Mar. 2010, pp. S140–44. Pubmed, doi:10.1016/j.ijrobp.2009.08.077.
Jeraj R, Cao Y, Ten Haken RK, Hahn C, Marks L. Imaging for assessment of radiation-induced normal tissue effects. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S140–S144.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

March 1, 2010

Volume

76

Issue

3 Suppl

Start / End Page

S140 / S144

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed, Single-Photon
  • Radiation Injuries
  • Positron-Emission Tomography
  • Oncology & Carcinogenesis
  • Magnetic Resonance Imaging
  • Humans
  • Diagnostic Imaging
  • Biomarkers
  • 5105 Medical and biological physics