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Tigecycline: a new glycylcycline antimicrobial.

Publication ,  Journal Article
Townsend, ML; Pound, MW; Drew, RH
Published in: Int J Clin Pract
December 2006

Tigecycline is a new glycyclcycline antimicrobial recently approved for use in the USA, Europe and elsewhere. While related to the tetracyclines, tigecycline overcomes many of the mechanisms responsible for resistance to this class. It demonstrates favourable in vitro potency against a variety of aerobic and anaerobic Gram-positive and Gram-negative pathogens, including those frequently demonstrating resistance to multiple classes of antimicrobials. This includes methicillin-resistant Staphylococcus aureus, penicillin-resistant S. pneumoniae, vancomycin-resistant enterococci, Acinetobacter baumannii, beta-lactamase producing strains of Haemophilis influenzae and Moraxella catarrhalis, and extended-spectrum beta-lactamase producing strains of Escherichia coli and Klebsiella pneumoniae. In contrast, minimum inhibitory concentrations for Pseudomonas and Proteus spp. are markedly elevated. Tigecycline is administered parenterally twice daily. Randomised, controlled trials have demonstrated that tigecycline is non-inferior to the comparators for the treatment of complicated skin and skin structure infections, as well as complicated intra-abdominal infections. The most frequent and problematic side effect associated with its administration to date has been nausea and/or vomiting.

Duke Scholars

Published In

Int J Clin Pract

DOI

ISSN

1368-5031

Publication Date

December 2006

Volume

60

Issue

12

Start / End Page

1662 / 1672

Location

India

Related Subject Headings

  • Tigecycline
  • Minocycline
  • Infections
  • Humans
  • General Clinical Medicine
  • Drug Costs
  • Anti-Infective Agents
  • 3202 Clinical sciences
  • 1701 Psychology
  • 1117 Public Health and Health Services
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Townsend, M. L., Pound, M. W., & Drew, R. H. (2006). Tigecycline: a new glycylcycline antimicrobial. Int J Clin Pract, 60(12), 1662–1672. https://doi.org/10.1111/j.1742-1241.2006.01188.x
Townsend, M. L., M. W. Pound, and R. H. Drew. “Tigecycline: a new glycylcycline antimicrobial.Int J Clin Pract 60, no. 12 (December 2006): 1662–72. https://doi.org/10.1111/j.1742-1241.2006.01188.x.
Townsend ML, Pound MW, Drew RH. Tigecycline: a new glycylcycline antimicrobial. Int J Clin Pract. 2006 Dec;60(12):1662–72.
Townsend, M. L., et al. “Tigecycline: a new glycylcycline antimicrobial.Int J Clin Pract, vol. 60, no. 12, Dec. 2006, pp. 1662–72. Pubmed, doi:10.1111/j.1742-1241.2006.01188.x.
Townsend ML, Pound MW, Drew RH. Tigecycline: a new glycylcycline antimicrobial. Int J Clin Pract. 2006 Dec;60(12):1662–1672.

Published In

Int J Clin Pract

DOI

ISSN

1368-5031

Publication Date

December 2006

Volume

60

Issue

12

Start / End Page

1662 / 1672

Location

India

Related Subject Headings

  • Tigecycline
  • Minocycline
  • Infections
  • Humans
  • General Clinical Medicine
  • Drug Costs
  • Anti-Infective Agents
  • 3202 Clinical sciences
  • 1701 Psychology
  • 1117 Public Health and Health Services