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Effects of inversions on within- and between-species recombination and divergence.

Publication ,  Journal Article
Stevison, LS; Hoehn, KB; Noor, MAF
Published in: Genome Biology and Evolution
January 2011

Chromosomal inversions disrupt recombination in heterozygotes by both reducing crossing-over within inverted regions and increasing it elsewhere in the genome. The reduction of recombination in inverted regions facilitates the maintenance of hybridizing species, as outlined by various models of chromosomal speciation. We present a comprehensive comparison of the effects of inversions on recombination rates and on nucleotide divergence. Within an inversion differentiating Drosophila pseudoobscura and Drosophila persimilis, we detected one double recombinant among 9,739 progeny from F(1) hybrids screened, consistent with published double-crossover frequencies observed within species. Despite similar rates of exchange within and between species, we found no sequence-based evidence of ongoing gene exchange between species within this inversion, but significant exchange was inferred within species. We also observed greater differentiation at regions near inversion breakpoints between species versus within species. Moreover, we observed strong "interchromosomal effect" (higher recombination in inversion heterozygotes between species) with up to 9-fold higher recombination rates along collinear segments of chromosome two in hybrids. Further, we observed that regions most susceptible to changes in recombination rates corresponded to regions with lower recombination rates in homokaryotypes. Finally, we showed that interspecies nucleotide divergence is lower in regions with greater increases in recombination rate, potentially resulting from greater interspecies exchange. Overall, we have identified several similarities and differences between inversions segregating within versus between species in their effects on recombination and divergence. We conclude that these differences are most likely due to lower frequency of heterokaryotypes and to fitness consequences from the accumulation of various incompatibilities between species. Additionally, we have identified possible effects of inversions on interspecies gene exchange that had not been considered previously.

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Published In

Genome Biology and Evolution

DOI

EISSN

1759-6653

ISSN

1759-6653

Publication Date

January 2011

Volume

3

Start / End Page

830 / 841

Related Subject Headings

  • Species Specificity
  • Sequence Analysis, DNA
  • Recombination, Genetic
  • Polymorphism, Single Nucleotide
  • Models, Genetic
  • Heterozygote
  • Genome
  • Gene Frequency
  • Evolution, Molecular
  • Drosophila
 

Citation

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Stevison, L. S., Hoehn, K. B., & Noor, M. A. F. (2011). Effects of inversions on within- and between-species recombination and divergence. Genome Biology and Evolution, 3, 830–841. https://doi.org/10.1093/gbe/evr081
Stevison, Laurie S., Kenneth B. Hoehn, and Mohamed A. F. Noor. “Effects of inversions on within- and between-species recombination and divergence.Genome Biology and Evolution 3 (January 2011): 830–41. https://doi.org/10.1093/gbe/evr081.
Stevison LS, Hoehn KB, Noor MAF. Effects of inversions on within- and between-species recombination and divergence. Genome Biology and Evolution. 2011 Jan;3:830–41.
Stevison, Laurie S., et al. “Effects of inversions on within- and between-species recombination and divergence.Genome Biology and Evolution, vol. 3, Jan. 2011, pp. 830–41. Epmc, doi:10.1093/gbe/evr081.
Stevison LS, Hoehn KB, Noor MAF. Effects of inversions on within- and between-species recombination and divergence. Genome Biology and Evolution. 2011 Jan;3:830–841.
Journal cover image

Published In

Genome Biology and Evolution

DOI

EISSN

1759-6653

ISSN

1759-6653

Publication Date

January 2011

Volume

3

Start / End Page

830 / 841

Related Subject Headings

  • Species Specificity
  • Sequence Analysis, DNA
  • Recombination, Genetic
  • Polymorphism, Single Nucleotide
  • Models, Genetic
  • Heterozygote
  • Genome
  • Gene Frequency
  • Evolution, Molecular
  • Drosophila