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Regional pulmonary distribution of iodine-125-labeled oleic acid. Its relationship to the pattern of oleic acid edema and pulmonary blood flow.

Publication ,  Journal Article
Tarver, RD; Tsai, J; Hedlund, LW; Sullivan, DC; Lischko, MM; Harris, CC; Effmann, EL; Putman, CE
Published in: Invest Radiol
February 1986

Oleic acid infusion in dogs produces a patchy, predominantly peripheral lesion on CT scans. This study correlates the pattern of oleic acid injury with the distribution of infused oleic acid and pulmonary blood flow. Radiolabeled oleic acid (I-125, 0.05 ml/kg) and radiolabeled 15-micron microspheres (Co-57) were infused into the right atria of 11 dogs. Oleic acid was given after the microspheres in six dogs and before microspheres in five dogs. Ten minutes after infusion, the lungs were removed. Four transverse slices (0.5 cm thick) of the lower lobes were taken from each dog and cubed. Samples were grouped into three regions of the transverse slice: outer, middle, and inner concentric rings. In both groups, I-125 (oleic acid) activity was greater in the outer than the middle and inner concentric layers (P less than 0.001). When Cobalt-57 microspheres were given before oleic acid, Cobalt-57 activity was marginally lower in the outer layer compared with the middle and inner layers. However, when oleic acid was given first, microsphere activity in the outer layer was significantly lower (P less than 0.001) than the middle layer. Thus, oleic acid was preferentially distributed to the peripheral regions of the lung, similar to the regions of injury on CT. This distribution did not correspond to the pattern of pulmonary blood flow as indicated by the microspheres. Immediately after oleic acid infusion, pulmonary blood flow to the periphery was reduced, reflecting a response to the predominantly peripheral injury by oleic acid.

Duke Scholars

Published In

Invest Radiol

DOI

ISSN

0020-9996

Publication Date

February 1986

Volume

21

Issue

2

Start / End Page

102 / 107

Location

United States

Related Subject Headings

  • Radionuclide Imaging
  • Pulmonary Edema
  • Pulmonary Circulation
  • Oleic Acids
  • Oleic Acid
  • Nuclear Medicine & Medical Imaging
  • Lung
  • Iodine Radioisotopes
  • Dogs
  • Cobalt Radioisotopes
 

Citation

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Tarver, R. D., Tsai, J., Hedlund, L. W., Sullivan, D. C., Lischko, M. M., Harris, C. C., … Putman, C. E. (1986). Regional pulmonary distribution of iodine-125-labeled oleic acid. Its relationship to the pattern of oleic acid edema and pulmonary blood flow. Invest Radiol, 21(2), 102–107. https://doi.org/10.1097/00004424-198602000-00004
Tarver, R. D., J. Tsai, L. W. Hedlund, D. C. Sullivan, M. M. Lischko, C. C. Harris, E. L. Effmann, and C. E. Putman. “Regional pulmonary distribution of iodine-125-labeled oleic acid. Its relationship to the pattern of oleic acid edema and pulmonary blood flow.Invest Radiol 21, no. 2 (February 1986): 102–7. https://doi.org/10.1097/00004424-198602000-00004.
Tarver RD, Tsai J, Hedlund LW, Sullivan DC, Lischko MM, Harris CC, et al. Regional pulmonary distribution of iodine-125-labeled oleic acid. Its relationship to the pattern of oleic acid edema and pulmonary blood flow. Invest Radiol. 1986 Feb;21(2):102–7.
Tarver, R. D., et al. “Regional pulmonary distribution of iodine-125-labeled oleic acid. Its relationship to the pattern of oleic acid edema and pulmonary blood flow.Invest Radiol, vol. 21, no. 2, Feb. 1986, pp. 102–07. Pubmed, doi:10.1097/00004424-198602000-00004.
Tarver RD, Tsai J, Hedlund LW, Sullivan DC, Lischko MM, Harris CC, Effmann EL, Putman CE. Regional pulmonary distribution of iodine-125-labeled oleic acid. Its relationship to the pattern of oleic acid edema and pulmonary blood flow. Invest Radiol. 1986 Feb;21(2):102–107.

Published In

Invest Radiol

DOI

ISSN

0020-9996

Publication Date

February 1986

Volume

21

Issue

2

Start / End Page

102 / 107

Location

United States

Related Subject Headings

  • Radionuclide Imaging
  • Pulmonary Edema
  • Pulmonary Circulation
  • Oleic Acids
  • Oleic Acid
  • Nuclear Medicine & Medical Imaging
  • Lung
  • Iodine Radioisotopes
  • Dogs
  • Cobalt Radioisotopes