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Photo cross-linkable Biodendrimers as ophthalmic adhesives for central lacerations and penetrating keratoplasties.

Publication ,  Journal Article
Degoricija, L; Johnson, CS; Wathier, M; Kim, T; Grinstaff, MW
Published in: Invest Ophthalmol Vis Sci
May 2007

PURPOSE: Biodendrimer-based hydrogel adhesives were derived from biocompatible building blocks and poly(ethylene glycol) of 3,400, 10,000 and 20,000 g/mole. The leaking pressures were determined for these adhesives when used to seal 4.1-mm central lacerations and penetrating keratoplasties (PKPs) in enucleated porcine eyes. METHODS: Three biodendrimers, ([G1]-PGLSA-MA)(2)-PEG(3,400), ([G1]-PGLSA-MA)(2)-PEG(10,000), and ([G1]-PGLSA-MA)(2)-PEG(20,000), at a range of weight percents were each photo cross-linked in the presence of a photo-initiator to form a hydrated network. These biodendrimer-based adhesives were applied directly to a 4.1-mm linear central laceration. In a PKP, the corneal button was initially secured with 8 or 16 sutures and then sealed with the adhesive. RESULTS: For the 4.1-mm central lacerations, the ([G1]-PGLSA-MA)(2)-PEG(3,400) at 20% and 40% wt/vol, the ([G1]-PGLSA-MA)(2)-PEG(10,000) at 10 and 20% wt/vol, and the ([G1]-PGLSA-MA)(2)-PEG(20,000) at 20% wt/vol held to leaking pressures above 200 mm Hg. In the autograft with 16 sutures, the 20% wt/vol of the ([G1]-PGLSA-MA)(2)-PEG(3,400), ([G1]-PGLSA-MA)(2)-PEG(10,000), and ([G1]-PGLSA-MA)(2)-PEG(20,000) held to a pressure at or above 100 mm Hg. In the autograft with eight sutures, the ([G1]-PGLSA-MA)(2)-PEG(10,000) and ([G1]-PGLSA-MA)(2)-PEG(20,000) formulations at 20% wt/vol held to leaking pressures of 85 +/- 22 and 80 +/- 30 mm Hg, respectively. CONCLUSIONS: The 10% wt/vol ([G1]-PGLSA-MA)(2)-PEG(10,000) formulation withheld leaking pressures above 200 mm Hg when used to secure a 4.1 mm central laceration. The 20% wt/vol ([G1]-PGLSA-MA)(2)-PEG(10,000) and ([G1]-PGLSA-MA)(2)-PEG(20,000) formulations, with 8 or 16 sutures, secured the PKP well above normal IOP. Biodendrimer-based adhesives are of potential use for repairing corneal wounds.

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Published In

Invest Ophthalmol Vis Sci

DOI

ISSN

0146-0404

Publication Date

May 2007

Volume

48

Issue

5

Start / End Page

2037 / 2042

Location

United States

Related Subject Headings

  • Wound Healing
  • Tissue Adhesives
  • Tensile Strength
  • Swine
  • Surgical Wound Dehiscence
  • Polyethylene Glycols
  • Ophthalmology & Optometry
  • Light
  • Lacerations
  • Keratoplasty, Penetrating
 

Citation

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Degoricija, L., Johnson, C. S., Wathier, M., Kim, T., & Grinstaff, M. W. (2007). Photo cross-linkable Biodendrimers as ophthalmic adhesives for central lacerations and penetrating keratoplasties. Invest Ophthalmol Vis Sci, 48(5), 2037–2042. https://doi.org/10.1167/iovs.06-0957
Degoricija, Lovorka, C Starck Johnson, Michel Wathier, Terry Kim, and Mark W. Grinstaff. “Photo cross-linkable Biodendrimers as ophthalmic adhesives for central lacerations and penetrating keratoplasties.Invest Ophthalmol Vis Sci 48, no. 5 (May 2007): 2037–42. https://doi.org/10.1167/iovs.06-0957.
Degoricija L, Johnson CS, Wathier M, Kim T, Grinstaff MW. Photo cross-linkable Biodendrimers as ophthalmic adhesives for central lacerations and penetrating keratoplasties. Invest Ophthalmol Vis Sci. 2007 May;48(5):2037–42.
Degoricija, Lovorka, et al. “Photo cross-linkable Biodendrimers as ophthalmic adhesives for central lacerations and penetrating keratoplasties.Invest Ophthalmol Vis Sci, vol. 48, no. 5, May 2007, pp. 2037–42. Pubmed, doi:10.1167/iovs.06-0957.
Degoricija L, Johnson CS, Wathier M, Kim T, Grinstaff MW. Photo cross-linkable Biodendrimers as ophthalmic adhesives for central lacerations and penetrating keratoplasties. Invest Ophthalmol Vis Sci. 2007 May;48(5):2037–2042.

Published In

Invest Ophthalmol Vis Sci

DOI

ISSN

0146-0404

Publication Date

May 2007

Volume

48

Issue

5

Start / End Page

2037 / 2042

Location

United States

Related Subject Headings

  • Wound Healing
  • Tissue Adhesives
  • Tensile Strength
  • Swine
  • Surgical Wound Dehiscence
  • Polyethylene Glycols
  • Ophthalmology & Optometry
  • Light
  • Lacerations
  • Keratoplasty, Penetrating