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Target size regulates calibre and myelination of sympathetic axons.

Publication ,  Journal Article
Voyvodic, JT
Published in: Nature
November 23, 1989

Axons in vertebrate peripheral nerves are ensheathed by Schwann cells. For some axons, this sheath consists of a single layer of glial cell cytoplasm and plasma membranes; for other axons, Schwann cells form multilayered myelin. Whether or not a Schwann cell makes myelin is determined by a signal from the axon, but the nature of this signal is not known. Here I show that sympathetic postganglionic axons, which are normally not myelinated, become myelinated when their calibre is increased as a result of increasing the size of the peripheral target they innervate. This result implies that axon calibre, which is known to be correlated with myelination, is in fact the crucial determinant of whether an axon becomes myelinated. Furthermore, the finding that increasing or decreasing target size causes corresponding increases or decreases in axon size indicates that axon calibre is itself regulated by retrograde signals from peripheral target tissues.

Duke Scholars

Published In

Nature

DOI

ISSN

0028-0836

Publication Date

November 23, 1989

Volume

342

Issue

6248

Start / End Page

430 / 433

Location

England

Related Subject Headings

  • Sympathetic Nervous System
  • Submandibular Gland
  • Reference Values
  • Rats
  • Myelin Sheath
  • Microscopy, Electron
  • General Science & Technology
  • Denervation
  • Axons
  • Animals
 

Citation

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MLA
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Voyvodic, J. T. (1989). Target size regulates calibre and myelination of sympathetic axons. Nature, 342(6248), 430–433. https://doi.org/10.1038/342430a0
Voyvodic, J. T. “Target size regulates calibre and myelination of sympathetic axons.Nature 342, no. 6248 (November 23, 1989): 430–33. https://doi.org/10.1038/342430a0.
Voyvodic JT. Target size regulates calibre and myelination of sympathetic axons. Nature. 1989 Nov 23;342(6248):430–3.
Voyvodic, J. T. “Target size regulates calibre and myelination of sympathetic axons.Nature, vol. 342, no. 6248, Nov. 1989, pp. 430–33. Pubmed, doi:10.1038/342430a0.
Voyvodic JT. Target size regulates calibre and myelination of sympathetic axons. Nature. 1989 Nov 23;342(6248):430–433.
Journal cover image

Published In

Nature

DOI

ISSN

0028-0836

Publication Date

November 23, 1989

Volume

342

Issue

6248

Start / End Page

430 / 433

Location

England

Related Subject Headings

  • Sympathetic Nervous System
  • Submandibular Gland
  • Reference Values
  • Rats
  • Myelin Sheath
  • Microscopy, Electron
  • General Science & Technology
  • Denervation
  • Axons
  • Animals