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Marked reduction in the number of platelet-tritiated imipramine binding sites in geriatric depression.

Publication ,  Journal Article
Nemeroff, CB; Knight, DL; Krishnan, RR; Slotkin, TA; Bissette, G; Melville, ML; Blazer, DG
Published in: Arch Gen Psychiatry
October 1988

The number (Bmax) and affinity (Kd) of platelet-tritiated imipramine binding sites was determined in young and middle-aged controls 50 years of age and younger (n = 25), elderly normal controls over 60 years of age (n = 18), patients who fulfilled DSM-III criteria for major depression who were under 50 years of age (n = 29), patients who fulfilled DSM-III criteria for major depression who were 60 years of age and older (n = 19), and patients who fulfilled both DSM-III criteria for primary degenerative dementia and National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for probable Alzheimer's disease (n = 13). Both groups of depressed patients (under 50 and over 60 years of age) exhibited significant reductions (decreases 42%) in the number of platelet-tritiated imipramine binding sites with no change in affinity, when compared with their age-matched controls. There was little overlap in Bmax values between the elderly depressed patients and their controls. The patients with probable Alzheimer's disease showed no alteration in platelet-tritiated imipramine binding. There was no statistically significant relationship between postdexamethasone plasma cortisol concentrations and tritiated imipramine binding. These results indicate that platelet-tritiated imipramine binding may have potential utility as a diagnostic adjunct in geriatric depression, and moreover that the reduction in the number of platelet-tritiated imipramine binding sites is not due to hypercortisolemia.

Duke Scholars

Published In

Arch Gen Psychiatry

DOI

ISSN

0003-990X

Publication Date

October 1988

Volume

45

Issue

10

Start / End Page

919 / 923

Location

United States

Related Subject Headings

  • Tritium
  • Receptors, Neurotransmitter
  • Receptors, Drug
  • Psychiatry
  • Middle Aged
  • Imipramine
  • Humans
  • Diagnosis, Differential
  • Depressive Disorder
  • Carrier Proteins
 

Citation

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MLA
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Nemeroff, C. B., Knight, D. L., Krishnan, R. R., Slotkin, T. A., Bissette, G., Melville, M. L., & Blazer, D. G. (1988). Marked reduction in the number of platelet-tritiated imipramine binding sites in geriatric depression. Arch Gen Psychiatry, 45(10), 919–923. https://doi.org/10.1001/archpsyc.1988.01800340045006
Nemeroff, C. B., D. L. Knight, R. R. Krishnan, T. A. Slotkin, G. Bissette, M. L. Melville, and D. G. Blazer. “Marked reduction in the number of platelet-tritiated imipramine binding sites in geriatric depression.Arch Gen Psychiatry 45, no. 10 (October 1988): 919–23. https://doi.org/10.1001/archpsyc.1988.01800340045006.
Nemeroff CB, Knight DL, Krishnan RR, Slotkin TA, Bissette G, Melville ML, et al. Marked reduction in the number of platelet-tritiated imipramine binding sites in geriatric depression. Arch Gen Psychiatry. 1988 Oct;45(10):919–23.
Nemeroff, C. B., et al. “Marked reduction in the number of platelet-tritiated imipramine binding sites in geriatric depression.Arch Gen Psychiatry, vol. 45, no. 10, Oct. 1988, pp. 919–23. Pubmed, doi:10.1001/archpsyc.1988.01800340045006.
Nemeroff CB, Knight DL, Krishnan RR, Slotkin TA, Bissette G, Melville ML, Blazer DG. Marked reduction in the number of platelet-tritiated imipramine binding sites in geriatric depression. Arch Gen Psychiatry. 1988 Oct;45(10):919–923.

Published In

Arch Gen Psychiatry

DOI

ISSN

0003-990X

Publication Date

October 1988

Volume

45

Issue

10

Start / End Page

919 / 923

Location

United States

Related Subject Headings

  • Tritium
  • Receptors, Neurotransmitter
  • Receptors, Drug
  • Psychiatry
  • Middle Aged
  • Imipramine
  • Humans
  • Diagnosis, Differential
  • Depressive Disorder
  • Carrier Proteins