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Depressive symptoms moderate the influence of the apolipoproteine epsilon4 allele on cognitive decline in a sample of community dwelling older adults.

Publication ,  Journal Article
Corsentino, EA; Sawyer, K; Sachs-Ericsson, N; Blazer, DG
Published in: Am J Geriatr Psychiatry
February 2009

OBJECTIVES: The apolipoproteinE epsilon4 (APOE epsilon4) allele and a history of depression are each separate risk factors for cognitive decline (CD). However, little research has investigated whether a history of depression influences the relationship between APOE epsilon4 and CD. The present study examined whether depressive symptoms had greater influence on subsequent CD among participants with APOE epsilon4 than those without the allele. DESIGN: Prospective 6-year longitudinal study. SETTING: Community in-home interviews. PARTICIPANTS: A biracial sample of community dwelling older adults (N = 1,992) from the Duke Established Populations for Epidemiologic Studies of the Elderly (EPESE). MEASUREMENTS: Data were drawn from Waves 1 to 3 of the EPESE, which were conducted 6 years apart. Cognitive functioning and depressive symptoms were assessed at both waves, and APOE genotyping was completed during the Wave 3 assessment. RESULTS: Regression analyses revealed that depressive symptoms and the APOE epsilon4 allele independently predicted CD. Importantly, the influence of depressive symptoms on CD was greater for individuals with the APOE epsilon4 allele compared with those without the allele. CONCLUSION: Depressive symptoms and the APOE epsilon4 allele are independent contributors to CD. Moreover, the influence of depressive symptoms on CD is greater among individuals with the APOE epsilon4 allele. Depression and the APOE epsilon4 allele may act together in disrupting neurological functioning, which may in turn lower an individual's cognitive reserve capacity. Given the efficacious treatments currently available for depression, future research should investigate the extent to which interventions for depression may reduce the risk for subsequent CD.

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Published In

Am J Geriatr Psychiatry

DOI

EISSN

1545-7214

Publication Date

February 2009

Volume

17

Issue

2

Start / End Page

155 / 165

Location

England

Related Subject Headings

  • Risk Factors
  • Regression Analysis
  • Prospective Studies
  • Mental Status Schedule
  • Humans
  • Geriatrics
  • Genotype
  • Genetic Predisposition to Disease
  • Depression
  • Data Collection
 

Citation

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Corsentino, E. A., Sawyer, K., Sachs-Ericsson, N., & Blazer, D. G. (2009). Depressive symptoms moderate the influence of the apolipoproteine epsilon4 allele on cognitive decline in a sample of community dwelling older adults. Am J Geriatr Psychiatry, 17(2), 155–165. https://doi.org/10.1097/JGP.0b013e31818f3a6b
Corsentino, Elizabeth A., Kathryn Sawyer, Natalie Sachs-Ericsson, and Dan G. Blazer. “Depressive symptoms moderate the influence of the apolipoproteine epsilon4 allele on cognitive decline in a sample of community dwelling older adults.Am J Geriatr Psychiatry 17, no. 2 (February 2009): 155–65. https://doi.org/10.1097/JGP.0b013e31818f3a6b.
Corsentino EA, Sawyer K, Sachs-Ericsson N, Blazer DG. Depressive symptoms moderate the influence of the apolipoproteine epsilon4 allele on cognitive decline in a sample of community dwelling older adults. Am J Geriatr Psychiatry. 2009 Feb;17(2):155–65.
Corsentino, Elizabeth A., et al. “Depressive symptoms moderate the influence of the apolipoproteine epsilon4 allele on cognitive decline in a sample of community dwelling older adults.Am J Geriatr Psychiatry, vol. 17, no. 2, Feb. 2009, pp. 155–65. Pubmed, doi:10.1097/JGP.0b013e31818f3a6b.
Corsentino EA, Sawyer K, Sachs-Ericsson N, Blazer DG. Depressive symptoms moderate the influence of the apolipoproteine epsilon4 allele on cognitive decline in a sample of community dwelling older adults. Am J Geriatr Psychiatry. 2009 Feb;17(2):155–165.
Journal cover image

Published In

Am J Geriatr Psychiatry

DOI

EISSN

1545-7214

Publication Date

February 2009

Volume

17

Issue

2

Start / End Page

155 / 165

Location

England

Related Subject Headings

  • Risk Factors
  • Regression Analysis
  • Prospective Studies
  • Mental Status Schedule
  • Humans
  • Geriatrics
  • Genotype
  • Genetic Predisposition to Disease
  • Depression
  • Data Collection