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Family and personal medical history and risk of meningioma.

Publication ,  Journal Article
Claus, EB; Calvocoressi, L; Bondy, ML; Schildkraut, JM; Wiemels, JL; Wrensch, M
Published in: J Neurosurg
December 2011

OBJECT: Little is known about the epidemiology of meningioma, the most frequently reported primary brain tumor in the US. The authors undertook a case-control study to examine the relationship between family and personal medical history and meningioma risk. METHODS: The authors compared the personal and first-degree family histories of 1124 patients with meningioma (age range 20-79 years) in Connecticut, Massachusetts, North Carolina, the San Francisco Bay Area, and 8 Houston counties between May 1, 2006, and February 26, 2010, and the histories of 1000 control individuals who were frequency-matched for age, sex, and geography. RESULTS: The patients were more likely than the controls to report a first-degree family history of meningioma (OR 4.4, 95% CI 1.6-11.5), and there was an even stronger association in younger cases. The patients were less likely than controls to report immune conditions including allergy (OR 0.6, 95% CI 0.5-0.7) but were more likely to report a history of thyroid cancer (OR 4.7, 95% CI 1.02-21.5) or leukemia (OR 5.4, 95% CI 1.2-24.1) (most after radiotherapy). Among women, patients were more likely than controls to report hormonally related conditions--uterine fibroid tumors (OR 1.2, 95% CI 1.0-1.5), endometriosis (OR 1.5, 95% CI 1.5-2.1), and breast cancer (OR 1.4, 95% CI 0.8-2.3). CONCLUSIONS: The influence of genetics, the immune system, and radiation near the head on meningioma risk is suggested in the authors' findings; the role of hormones is intriguing but requires further study.

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Published In

J Neurosurg

DOI

EISSN

1933-0693

Publication Date

December 2011

Volume

115

Issue

6

Start / End Page

1072 / 1077

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Socioeconomic Factors
  • Risk Factors
  • Neurology & Neurosurgery
  • Middle Aged
  • Meningioma
  • Meningeal Neoplasms
  • Medical History Taking
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Claus, E. B., Calvocoressi, L., Bondy, M. L., Schildkraut, J. M., Wiemels, J. L., & Wrensch, M. (2011). Family and personal medical history and risk of meningioma. J Neurosurg, 115(6), 1072–1077. https://doi.org/10.3171/2011.6.JNS11129
Claus, Elizabeth B., Lisa Calvocoressi, Melissa L. Bondy, Joellen M. Schildkraut, Joseph L. Wiemels, and Margaret Wrensch. “Family and personal medical history and risk of meningioma.J Neurosurg 115, no. 6 (December 2011): 1072–77. https://doi.org/10.3171/2011.6.JNS11129.
Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Family and personal medical history and risk of meningioma. J Neurosurg. 2011 Dec;115(6):1072–7.
Claus, Elizabeth B., et al. “Family and personal medical history and risk of meningioma.J Neurosurg, vol. 115, no. 6, Dec. 2011, pp. 1072–77. Pubmed, doi:10.3171/2011.6.JNS11129.
Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Family and personal medical history and risk of meningioma. J Neurosurg. 2011 Dec;115(6):1072–1077.

Published In

J Neurosurg

DOI

EISSN

1933-0693

Publication Date

December 2011

Volume

115

Issue

6

Start / End Page

1072 / 1077

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Socioeconomic Factors
  • Risk Factors
  • Neurology & Neurosurgery
  • Middle Aged
  • Meningioma
  • Meningeal Neoplasms
  • Medical History Taking
  • Male