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Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system.

Publication ,  Journal Article
Svetkey, LP; Harris, EL; Martin, E; Vollmer, WM; Meltesen, GT; Ricchiuti, V; Williams, G; Appel, LJ; Bray, GA; Moore, TJ; Winn, MP; Conlin, PR
Published in: Am J Hypertens
February 2011

BACKGROUND: Essential hypertension results from the interaction of several genetic and environmental factors. Identification of genetic factors that modulate blood pressure (BP) response to interventions can lead to improved strategies for prevention and control. The purpose of this study was to identify genes that modulate BP response to dietary interventions. METHODS: We used data and samples collected in two randomized feeding studies to determine the extent to which genetic architecture is associated with the effect on BP of sodium intake and the Dietary Approaches to Stop Hypertension (DASH) dietary pattern. Participants in both trials were adults with above-optimal BP or unmedicated stage 1 hypertension. Genomic DNA was typed for several candidate genes. RESULTS: The effect of sodium intake on BP differed by genotype at the angiotensinogen, β2-adrenergic receptor, and kallikrein loci. The effect of DASH dietary pattern on BP differed by genotype at the β2-adrenergic receptor locus. CONCLUSIONS: These findings have implications for understanding the mechanism(s) through which diet affects BP, the heterogeneity of these effects, and the extent to which dietary interventions can modulate genetic predisposition.

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Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

February 2011

Volume

24

Issue

2

Start / End Page

209 / 217

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Sympathetic Nervous System
  • Sodium, Dietary
  • Risk Factors
  • Risk Assessment
  • Renin-Angiotensin System
  • Receptors, Adrenergic, beta-2
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Middle Aged
 

Citation

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Svetkey, L. P., Harris, E. L., Martin, E., Vollmer, W. M., Meltesen, G. T., Ricchiuti, V., … Conlin, P. R. (2011). Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system. Am J Hypertens, 24(2), 209–217. https://doi.org/10.1038/ajh.2010.223
Svetkey, Laura P., Emily L. Harris, Eden Martin, William M. Vollmer, Gayle T. Meltesen, Vincent Ricchiuti, Gordon Williams, et al. “Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system.Am J Hypertens 24, no. 2 (February 2011): 209–17. https://doi.org/10.1038/ajh.2010.223.
Svetkey LP, Harris EL, Martin E, Vollmer WM, Meltesen GT, Ricchiuti V, et al. Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system. Am J Hypertens. 2011 Feb;24(2):209–17.
Svetkey, Laura P., et al. “Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system.Am J Hypertens, vol. 24, no. 2, Feb. 2011, pp. 209–17. Pubmed, doi:10.1038/ajh.2010.223.
Svetkey LP, Harris EL, Martin E, Vollmer WM, Meltesen GT, Ricchiuti V, Williams G, Appel LJ, Bray GA, Moore TJ, Winn MP, Conlin PR. Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system. Am J Hypertens. 2011 Feb;24(2):209–217.
Journal cover image

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

February 2011

Volume

24

Issue

2

Start / End Page

209 / 217

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Sympathetic Nervous System
  • Sodium, Dietary
  • Risk Factors
  • Risk Assessment
  • Renin-Angiotensin System
  • Receptors, Adrenergic, beta-2
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Middle Aged