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Biochemical profile of stone-forming patients with diabetes mellitus.

Publication ,  Journal Article
Pak, CYC; Sakhaee, K; Moe, O; Preminger, GM; Poindexter, JR; Peterson, RD; Pietrow, P; Ekeruo, W
Published in: Urology
March 2003

OBJECTIVES: To test the hypothesis that stone-forming patients with type II diabetes (DM-II) have a high prevalence of uric acid (UA) stones and present with some of the biochemical features of gouty diathesis (GD). METHODS: The demographic and initial biochemical data from 59 stone-forming patients with DM-II (serum glucose greater than 126 mg/dL, no insulin therapy, older than 35 years of age) from Dallas, Texas and Durham, North Carolina were retrieved and compared with data from 58 patients with GD and 116 with hyperuricosuric calcium oxalate urolithiasis (HUCU) without DM. RESULTS: UA stones were detected in 33.9% of patients with DM-II compared with 6.2% of stone-forming patients without DM (P <0.001). Despite similar ingestion of alkali, the urinary pH in patients with DM-II and UA stones (n = 20) was low (pH = 5.5), as it is in patients with GD, and was significantly lower than in patients with HUCU. The urinary pH in patients with DM-II and calcium stones (n = 39) was intermediate between that in those with DM-II and UA stones and those with HUCU. However, both DM groups had fractional excretion of urate that was not depressed, as it is in those with GD, and was comparable to the value obtained in those with HUCU. The urinary content of undissociated UA was significantly higher, and the saturation of calcium phosphate (brushite) and sodium urate was significantly lower in those with DM-II and UA stones than in those with HUCU. CONCLUSIONS: Stone-forming patients with DM-II have a high prevalence of UA stones. Diabetic patients with UA stones share a key feature of those with GD, namely the passage of unusually acid urine, but not the low fractional excretion of urate.

Duke Scholars

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

March 2003

Volume

61

Issue

3

Start / End Page

523 / 527

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urine
  • Urinary Calculi
  • Uric Acid
  • Prevalence
  • Middle Aged
  • Male
  • Hydrogen-Ion Concentration
  • Humans
  • Gout
 

Citation

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Pak, C. Y. C., Sakhaee, K., Moe, O., Preminger, G. M., Poindexter, J. R., Peterson, R. D., … Ekeruo, W. (2003). Biochemical profile of stone-forming patients with diabetes mellitus. Urology, 61(3), 523–527. https://doi.org/10.1016/s0090-4295(02)02421-4
Pak, Charles Y. C., Khashayar Sakhaee, Orson Moe, Glenn M. Preminger, John R. Poindexter, Roy D. Peterson, Paul Pietrow, and Wesley Ekeruo. “Biochemical profile of stone-forming patients with diabetes mellitus.Urology 61, no. 3 (March 2003): 523–27. https://doi.org/10.1016/s0090-4295(02)02421-4.
Pak CYC, Sakhaee K, Moe O, Preminger GM, Poindexter JR, Peterson RD, et al. Biochemical profile of stone-forming patients with diabetes mellitus. Urology. 2003 Mar;61(3):523–7.
Pak, Charles Y. C., et al. “Biochemical profile of stone-forming patients with diabetes mellitus.Urology, vol. 61, no. 3, Mar. 2003, pp. 523–27. Pubmed, doi:10.1016/s0090-4295(02)02421-4.
Pak CYC, Sakhaee K, Moe O, Preminger GM, Poindexter JR, Peterson RD, Pietrow P, Ekeruo W. Biochemical profile of stone-forming patients with diabetes mellitus. Urology. 2003 Mar;61(3):523–527.
Journal cover image

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

March 2003

Volume

61

Issue

3

Start / End Page

523 / 527

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urine
  • Urinary Calculi
  • Uric Acid
  • Prevalence
  • Middle Aged
  • Male
  • Hydrogen-Ion Concentration
  • Humans
  • Gout