Assembly and disassembly of DNA polymerase holoenzyme.
Publication
, Journal Article
Sexton, DJ; Berdis, AJ; Benkovic, SJ
Published in: Curr Opin Chem Biol
October 1997
The complex task of genomic replication requires a large collection of proteins properly assembled within the close confines of the replication fork. The mechanism and dynamics of holoenzyme assembly and disassembly have been investigated using steady state and pre-steady state methods as opposed to structural studies, primarily due to the intrinsic transient nature of these protein complexes during DNA replication. The key step in bacteriophage T4 holoenzyme assembly involves ATP hydrolysis, whereas disassembly is mediated by subunit dissociation of the clamp protein in an ATP-independent manner.
Duke Scholars
Published In
Curr Opin Chem Biol
DOI
ISSN
1367-5931
Publication Date
October 1997
Volume
1
Issue
3
Start / End Page
316 / 322
Location
England
Related Subject Headings
- Protein Processing, Post-Translational
- Organic Chemistry
- DNA-Directed DNA Polymerase
- Coenzymes
- Bacteriophage T4
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
- 0304 Medicinal and Biomolecular Chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Sexton, D. J., Berdis, A. J., & Benkovic, S. J. (1997). Assembly and disassembly of DNA polymerase holoenzyme. Curr Opin Chem Biol, 1(3), 316–322. https://doi.org/10.1016/s1367-5931(97)80068-3
Sexton, D. J., A. J. Berdis, and S. J. Benkovic. “Assembly and disassembly of DNA polymerase holoenzyme.” Curr Opin Chem Biol 1, no. 3 (October 1997): 316–22. https://doi.org/10.1016/s1367-5931(97)80068-3.
Sexton DJ, Berdis AJ, Benkovic SJ. Assembly and disassembly of DNA polymerase holoenzyme. Curr Opin Chem Biol. 1997 Oct;1(3):316–22.
Sexton, D. J., et al. “Assembly and disassembly of DNA polymerase holoenzyme.” Curr Opin Chem Biol, vol. 1, no. 3, Oct. 1997, pp. 316–22. Pubmed, doi:10.1016/s1367-5931(97)80068-3.
Sexton DJ, Berdis AJ, Benkovic SJ. Assembly and disassembly of DNA polymerase holoenzyme. Curr Opin Chem Biol. 1997 Oct;1(3):316–322.
Published In
Curr Opin Chem Biol
DOI
ISSN
1367-5931
Publication Date
October 1997
Volume
1
Issue
3
Start / End Page
316 / 322
Location
England
Related Subject Headings
- Protein Processing, Post-Translational
- Organic Chemistry
- DNA-Directed DNA Polymerase
- Coenzymes
- Bacteriophage T4
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
- 0304 Medicinal and Biomolecular Chemistry