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High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility.

Publication ,  Journal Article
Liu, C; Li, W; Johnson, GA; Wu, B
Published in: Neuroimage
June 1, 2011

The multilayered myelin sheath wrapping around nerve axons is essential for proper functioning of the central nervous system. Abnormal myelination leads to a wide range of neurological diseases and developmental disorders. Non-invasive imaging of myelin content is of great clinical importance. The present work demonstrated that loss of myelin in the central nervous system of the shiverer mouse results in a dramatic reduction of magnetic susceptibility in white matter axons. The reduction resulted in a near extinction of susceptibility contrast between gray and white matter. Quantitative magnetic susceptibility imaging and diffusion tensor imaging were conducted on a group of control and shiverer mice at 9.4 T. We measured the resonance frequency distribution of the whole brain for each mouse. Magnetic susceptibility maps were computed and compared between the two groups. It was shown that the susceptibility contrast between gray and white matter was reduced by 96% in the shiverer compared to the controls. Diffusion measurements further confirmed intact fiber pathways in the shiverer mice, ruling out the possibility of axonal injury and its potential contribution to the altered susceptibility. As an autosomal recessive mutation, shiverer is characterized by an almost total lack of central nervous system myelin. Our data provide new evidences indicating that myelin is the predominant source of susceptibility differences between deep gray and white matter observed in magnetic resonance imaging. More importantly, the present study suggests that quantitative magnetic susceptibility is a potential endogenous biomarker for myelination.

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Published In

Neuroimage

DOI

EISSN

1095-9572

Publication Date

June 1, 2011

Volume

56

Issue

3

Start / End Page

930 / 938

Location

United States

Related Subject Headings

  • Tissue Fixation
  • Neurology & Neurosurgery
  • Myelin Sheath
  • Mice, Neurologic Mutants
  • Mice, Inbred C3H
  • Mice
  • Image Processing, Computer-Assisted
  • Fourier Analysis
  • Electromagnetic Fields
  • Echo-Planar Imaging
 

Citation

APA
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ICMJE
MLA
NLM
Liu, C., Li, W., Johnson, G. A., & Wu, B. (2011). High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility. Neuroimage, 56(3), 930–938. https://doi.org/10.1016/j.neuroimage.2011.02.024
Liu, Chunlei, Wei Li, G Allan Johnson, and Bing Wu. “High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility.Neuroimage 56, no. 3 (June 1, 2011): 930–38. https://doi.org/10.1016/j.neuroimage.2011.02.024.
Liu C, Li W, Johnson GA, Wu B. High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility. Neuroimage. 2011 Jun 1;56(3):930–8.
Liu, Chunlei, et al. “High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility.Neuroimage, vol. 56, no. 3, June 2011, pp. 930–38. Pubmed, doi:10.1016/j.neuroimage.2011.02.024.
Liu C, Li W, Johnson GA, Wu B. High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility. Neuroimage. 2011 Jun 1;56(3):930–938.
Journal cover image

Published In

Neuroimage

DOI

EISSN

1095-9572

Publication Date

June 1, 2011

Volume

56

Issue

3

Start / End Page

930 / 938

Location

United States

Related Subject Headings

  • Tissue Fixation
  • Neurology & Neurosurgery
  • Myelin Sheath
  • Mice, Neurologic Mutants
  • Mice, Inbred C3H
  • Mice
  • Image Processing, Computer-Assisted
  • Fourier Analysis
  • Electromagnetic Fields
  • Echo-Planar Imaging