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Non-surgical management of stress urinary incontinence: ambulatory treatments for leakage associated with stress (ATLAS) trial.

Publication ,  Journal Article
Richter, HE; Burgio, KL; Goode, PS; Borello-France, D; Bradley, CS; Brubaker, L; Handa, VL; Fine, PM; Visco, AG; Zyczynski, HM; Wei, JT ...
Published in: Clin Trials
2007

BACKGROUND: Non-surgical treatment for stress urinary incontinence (SUI) is recommended as first-line therapy, yet few prospective studies and no randomized trials compare the most common non-surgical treatments for SUI. PURPOSE: To present the design and methodology of the ambulatory treatments for leakage associated with stress (ATLAS) trial, a randomized clinical trial comparing three interventions for predominant SUI in women: intravaginal continence pessary; behavioral therapy (including pelvic floor muscle training and exercise and bladder control strategies); and a combination of the two treatments. METHODS: Treatment outcome measures, collected at 12 weeks and six and 12 months post randomization, include the Patient Global Impression of Improvement (PGI-I), the Stress Incontinence Scale of the Pelvic Floor Distress Inventory (PFDI), seven-day bladder diaries, Pelvic Floor Impact Questionnaire (PFIQ), Pelvic Organ Prolapse-Urinary Incontinence Sexual Function Questionnaire (PISQ-12), Patient Satisfaction Questionnaire (PSQ) and the Medical Outcomes Study Short Form Health Survey (SF-36). LIMITATIONS: The study design reduces most common biases, but some degree of selection bias may remain. CONCLUSION: This trial will provide useful information to help counsel women with stress and mixed incontinence about the relative efficacy and satisfaction with pessary, behavioral therapy and both treatments combined.

Duke Scholars

Published In

Clin Trials

DOI

ISSN

1740-7745

Publication Date

2007

Volume

4

Issue

1

Start / End Page

92 / 101

Location

England

Related Subject Headings

  • Urinary Incontinence, Stress
  • Treatment Outcome
  • Surveys and Questionnaires
  • Statistics & Probability
  • Selection Bias
  • Sample Size
  • Research Design
  • Quality of Life
  • Patient Satisfaction
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Richter, H. E., Burgio, K. L., Goode, P. S., Borello-France, D., Bradley, C. S., Brubaker, L., … Pelvic Foor Desorders Network, . (2007). Non-surgical management of stress urinary incontinence: ambulatory treatments for leakage associated with stress (ATLAS) trial. Clin Trials, 4(1), 92–101. https://doi.org/10.1177/1740774506075237
Richter, Holly E., Kathryn L. Burgio, Patricia S. Goode, Diane Borello-France, Catherine S. Bradley, Linda Brubaker, Victoria L. Handa, et al. “Non-surgical management of stress urinary incontinence: ambulatory treatments for leakage associated with stress (ATLAS) trial.Clin Trials 4, no. 1 (2007): 92–101. https://doi.org/10.1177/1740774506075237.
Richter HE, Burgio KL, Goode PS, Borello-France D, Bradley CS, Brubaker L, et al. Non-surgical management of stress urinary incontinence: ambulatory treatments for leakage associated with stress (ATLAS) trial. Clin Trials. 2007;4(1):92–101.
Richter, Holly E., et al. “Non-surgical management of stress urinary incontinence: ambulatory treatments for leakage associated with stress (ATLAS) trial.Clin Trials, vol. 4, no. 1, 2007, pp. 92–101. Pubmed, doi:10.1177/1740774506075237.
Richter HE, Burgio KL, Goode PS, Borello-France D, Bradley CS, Brubaker L, Handa VL, Fine PM, Visco AG, Zyczynski HM, Wei JT, Weber AM, Pelvic Foor Desorders Network. Non-surgical management of stress urinary incontinence: ambulatory treatments for leakage associated with stress (ATLAS) trial. Clin Trials. 2007;4(1):92–101.
Journal cover image

Published In

Clin Trials

DOI

ISSN

1740-7745

Publication Date

2007

Volume

4

Issue

1

Start / End Page

92 / 101

Location

England

Related Subject Headings

  • Urinary Incontinence, Stress
  • Treatment Outcome
  • Surveys and Questionnaires
  • Statistics & Probability
  • Selection Bias
  • Sample Size
  • Research Design
  • Quality of Life
  • Patient Satisfaction
  • Humans