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Toward discovery science of human brain function.

Publication ,  Journal Article
Biswal, BB; Mennes, M; Zuo, X-N; Gohel, S; Kelly, C; Smith, SM; Beckmann, CF; Adelstein, JS; Buckner, RL; Colcombe, S; Dogonowski, A-M ...
Published in: Proc Natl Acad Sci U S A
March 9, 2010

Although it is being successfully implemented for exploration of the genome, discovery science has eluded the functional neuroimaging community. The core challenge remains the development of common paradigms for interrogating the myriad functional systems in the brain without the constraints of a priori hypotheses. Resting-state functional MRI (R-fMRI) constitutes a candidate approach capable of addressing this challenge. Imaging the brain during rest reveals large-amplitude spontaneous low-frequency (<0.1 Hz) fluctuations in the fMRI signal that are temporally correlated across functionally related areas. Referred to as functional connectivity, these correlations yield detailed maps of complex neural systems, collectively constituting an individual's "functional connectome." Reproducibility across datasets and individuals suggests the functional connectome has a common architecture, yet each individual's functional connectome exhibits unique features, with stable, meaningful interindividual differences in connectivity patterns and strengths. Comprehensive mapping of the functional connectome, and its subsequent exploitation to discern genetic influences and brain-behavior relationships, will require multicenter collaborative datasets. Here we initiate this endeavor by gathering R-fMRI data from 1,414 volunteers collected independently at 35 international centers. We demonstrate a universal architecture of positive and negative functional connections, as well as consistent loci of inter-individual variability. Age and sex emerged as significant determinants. These results demonstrate that independent R-fMRI datasets can be aggregated and shared. High-throughput R-fMRI can provide quantitative phenotypes for molecular genetic studies and biomarkers of developmental and pathological processes in the brain. To initiate discovery science of brain function, the 1000 Functional Connectomes Project dataset is freely accessible at www.nitrc.org/projects/fcon_1000/.

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Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

March 9, 2010

Volume

107

Issue

10

Start / End Page

4734 / 4739

Location

United States

Related Subject Headings

  • Young Adult
  • Sex Factors
  • Neural Pathways
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Brain Mapping
  • Brain
 

Citation

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Biswal, B. B., Mennes, M., Zuo, X.-N., Gohel, S., Kelly, C., Smith, S. M., … Milham, M. P. (2010). Toward discovery science of human brain function. Proc Natl Acad Sci U S A, 107(10), 4734–4739. https://doi.org/10.1073/pnas.0911855107
Biswal, Bharat B., Maarten Mennes, Xi-Nian Zuo, Suril Gohel, Clare Kelly, Steve M. Smith, Christian F. Beckmann, et al. “Toward discovery science of human brain function.Proc Natl Acad Sci U S A 107, no. 10 (March 9, 2010): 4734–39. https://doi.org/10.1073/pnas.0911855107.
Biswal BB, Mennes M, Zuo X-N, Gohel S, Kelly C, Smith SM, et al. Toward discovery science of human brain function. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4734–9.
Biswal, Bharat B., et al. “Toward discovery science of human brain function.Proc Natl Acad Sci U S A, vol. 107, no. 10, Mar. 2010, pp. 4734–39. Pubmed, doi:10.1073/pnas.0911855107.
Biswal BB, Mennes M, Zuo X-N, Gohel S, Kelly C, Smith SM, Beckmann CF, Adelstein JS, Buckner RL, Colcombe S, Dogonowski A-M, Ernst M, Fair D, Hampson M, Hoptman MJ, Hyde JS, Kiviniemi VJ, Kötter R, Li S-J, Lin C-P, Lowe MJ, Mackay C, Madden DJ, Madsen KH, Margulies DS, Mayberg HS, McMahon K, Monk CS, Mostofsky SH, Nagel BJ, Pekar JJ, Peltier SJ, Petersen SE, Riedl V, Rombouts SARB, Rypma B, Schlaggar BL, Schmidt S, Seidler RD, Siegle GJ, Sorg C, Teng G-J, Veijola J, Villringer A, Walter M, Wang L, Weng X-C, Whitfield-Gabrieli S, Williamson P, Windischberger C, Zang Y-F, Zhang H-Y, Castellanos FX, Milham MP. Toward discovery science of human brain function. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4734–4739.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

March 9, 2010

Volume

107

Issue

10

Start / End Page

4734 / 4739

Location

United States

Related Subject Headings

  • Young Adult
  • Sex Factors
  • Neural Pathways
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Brain Mapping
  • Brain