Skip to main content
Journal cover image

Incidence of nonarteritic anterior ischemic optic neuropathy: increased risk among diabetic patients.

Publication ,  Journal Article
Lee, MS; Grossman, D; Arnold, AC; Sloan, FA
Published in: Ophthalmology
May 2011

Previous studies have identified a higher prevalence of diabetes mellitus (DM) among patient cohorts with nonarteritic anterior ischemic optic neuropathy (NAION). We sought to determine the development of incident NAION among a group of newly diagnosed patients with DM and to estimate the incidence of NAION among the elderly.Medicare 5% database study.A total of 25 515 patients with DM and an equal number of age- and gender-matched nondiabetic patients.Query of Medicare 5% claims files identified patients with a new diagnosis of DM in 1994. A randomly selected control group was created using 1-to-1 propensity score matching. Patients with a diagnosis of giant cell arteritis, preexisting DM, and age 68 years or older or >95 years were excluded. Patients with DM and controls were followed for the development of NAION over the following 4745 days.Incidence of NAION among patients with and without DM.In each group, 85% were white, 11% were black, and 4% were other race. Patients were aged 76.4 years, and 40% were male. Mean follow-up was 7.6 years. In the diabetes group, 188 individuals developed NAION (0.7%) compared with 131 individuals (0.5%; P < 0.01) in the control group. In unadjusted Cox regression analysis, having DM was associated with a 43% increased risk (hazard ratio [HR]: 1.431; 95% confidence interval [CI], 1.145-1.789) of developing NAION. After adjusting for other covariates, the risk of developing NAION among individuals with DM was reduced to 40% (HR 1.397; 95% CI, 1.115-1.750). Male gender increased an individual's risk of developing NAION by 32% (HR 1.319; 95% CI, 1.052-1.654). No other covariate was statistically significantly associated with developing NAION. The annual incidence of NAION was 82 per 100 000 persons.Diabetes mellitus significantly increased the risk of the diagnosis NAION. The incidence of NAION among patients aged more than 67 years may be higher than previously reported.

Duke Scholars

Published In

Ophthalmology

DOI

EISSN

1549-4713

ISSN

0161-6420

Publication Date

May 2011

Volume

118

Issue

5

Start / End Page

959 / 963

Related Subject Headings

  • United States
  • Sex Distribution
  • Risk Factors
  • Optic Neuropathy, Ischemic
  • Ophthalmology & Optometry
  • Medicare
  • Male
  • Incidence
  • Humans
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lee, M. S., Grossman, D., Arnold, A. C., & Sloan, F. A. (2011). Incidence of nonarteritic anterior ischemic optic neuropathy: increased risk among diabetic patients. Ophthalmology, 118(5), 959–963. https://doi.org/10.1016/j.ophtha.2011.01.054
Lee, Michael S., Daniel Grossman, Anthony C. Arnold, and Frank A. Sloan. “Incidence of nonarteritic anterior ischemic optic neuropathy: increased risk among diabetic patients.Ophthalmology 118, no. 5 (May 2011): 959–63. https://doi.org/10.1016/j.ophtha.2011.01.054.
Lee MS, Grossman D, Arnold AC, Sloan FA. Incidence of nonarteritic anterior ischemic optic neuropathy: increased risk among diabetic patients. Ophthalmology. 2011 May;118(5):959–63.
Lee, Michael S., et al. “Incidence of nonarteritic anterior ischemic optic neuropathy: increased risk among diabetic patients.Ophthalmology, vol. 118, no. 5, May 2011, pp. 959–63. Epmc, doi:10.1016/j.ophtha.2011.01.054.
Lee MS, Grossman D, Arnold AC, Sloan FA. Incidence of nonarteritic anterior ischemic optic neuropathy: increased risk among diabetic patients. Ophthalmology. 2011 May;118(5):959–963.
Journal cover image

Published In

Ophthalmology

DOI

EISSN

1549-4713

ISSN

0161-6420

Publication Date

May 2011

Volume

118

Issue

5

Start / End Page

959 / 963

Related Subject Headings

  • United States
  • Sex Distribution
  • Risk Factors
  • Optic Neuropathy, Ischemic
  • Ophthalmology & Optometry
  • Medicare
  • Male
  • Incidence
  • Humans
  • Follow-Up Studies