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Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population.

Publication ,  Journal Article
Gilligan, T; Manola, J; Sartor, O; Weinrich, SP; Moul, JW; Kantoff, PW
Published in: Clin Prostate Cancer
September 2004

Shorter androgen receptor gene CAG repeat length has been associated with an increased risk of prostate cancer, an earlier age of onset, and more advanced stage of disease. Studies comparing the distribution of CAG repeat lengths within different populations have reported that racial groups with higher prostate cancer incidence also have shorter CAG repeat lengths. We evaluated CAG repeat length in 685 black men in Louisiana, South Carolina, and the District of Columbia who were participating in prostate cancer screening, comparing the 118 who were diagnosed with prostate cancer with 567 who had normal serum prostate-specific antigen levels and no evidence of cancer on digital rectal examination. The median CAG repeat length was 21 among cases and 19 among controls (P = 0.11). Cases were significantly older than controls, with a median age of 68 years compared with 54 years (P < 0.0001). After adjusting for age, we found no association between prostate cancer risk and CAG repeat length (odds ratio, 1.05; 95% CI, 0.98-1.13; P = 0.16). Dividing CAG repeat lengths into septiles and calculating the odds ratio for each revealed no specific repeat-length range with a significantly elevated or depressed risk of prostate cancer, but a trend test showed a significant association between longer CAG repeat lengths and an elevated risk of prostate cancer (P = 0.02). Neither grade nor stage was associated with CAG repeat length. This study confirms earlier reports that black men have shorter CAG repeat lengths than reported white and Asian populations. We did not find an increased risk of prostate cancer among black men with fewer CAG repeats.

Duke Scholars

Published In

Clin Prostate Cancer

DOI

ISSN

1540-0352

Publication Date

September 2004

Volume

3

Issue

2

Start / End Page

98 / 103

Location

United States

Related Subject Headings

  • United States
  • Survival Analysis
  • Risk Assessment
  • Repetitive Sequences, Nucleic Acid
  • Reference Values
  • Receptors, Androgen
  • Prostatic Neoplasms
  • Prognosis
  • Probability
  • Polymorphism, Genetic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gilligan, T., Manola, J., Sartor, O., Weinrich, S. P., Moul, J. W., & Kantoff, P. W. (2004). Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population. Clin Prostate Cancer, 3(2), 98–103. https://doi.org/10.3816/cgc.2004.n.019
Gilligan, Timothy, Judith Manola, Oliver Sartor, Sally P. Weinrich, Judd W. Moul, and Philip W. Kantoff. “Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population.Clin Prostate Cancer 3, no. 2 (September 2004): 98–103. https://doi.org/10.3816/cgc.2004.n.019.
Gilligan T, Manola J, Sartor O, Weinrich SP, Moul JW, Kantoff PW. Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population. Clin Prostate Cancer. 2004 Sep;3(2):98–103.
Gilligan, Timothy, et al. “Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population.Clin Prostate Cancer, vol. 3, no. 2, Sept. 2004, pp. 98–103. Pubmed, doi:10.3816/cgc.2004.n.019.
Gilligan T, Manola J, Sartor O, Weinrich SP, Moul JW, Kantoff PW. Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population. Clin Prostate Cancer. 2004 Sep;3(2):98–103.

Published In

Clin Prostate Cancer

DOI

ISSN

1540-0352

Publication Date

September 2004

Volume

3

Issue

2

Start / End Page

98 / 103

Location

United States

Related Subject Headings

  • United States
  • Survival Analysis
  • Risk Assessment
  • Repetitive Sequences, Nucleic Acid
  • Reference Values
  • Receptors, Androgen
  • Prostatic Neoplasms
  • Prognosis
  • Probability
  • Polymorphism, Genetic