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Predicting non-organ-confined prostate cancer in men diagnosed after 2000.

Publication ,  Journal Article
Caire, AA; Sun, L; Lack, BD; Lum, K; Tang, P; Stackhouse, DA; Robertson, CN; Mouraviev, V; Polascik, TJ; Albala, DM; Moul, JW
Published in: Prostate Cancer Prostatic Dis
September 2010

The objective of this study was to preoperatively predict non-organ-confined disease in patients considering radical prostatectomy. To account for the stage migration seen in prostate cancer, we included only those patients who underwent prostatectomy after the year 2000. Information on a cohort of 1895 patients who underwent radical prostatectomy from 2000 to 2008 was retrieved from the Duke Prostate Center database. Race (African American, non-African American), body mass index, age at surgery, PSA, biopsy Gleason sum (<7, 7 and >7) and clinical tumor stage (cT1, cT2/3) were analyzed by univariate analysis followed by logistic regression analysis. The Duke Interactive Clinical Equation for staging (DICE-S score) was calculated from the logistic regression model. The model was then internally validated using a bootstrapping technique. Biopsy Gleason sums 7 and >7 were more likely to have non-organ-confined disease compared with <7 (OR=2.97, Gleason sum=7; OR=3.25, Gleason sum>7). Clinical tumor stage, cT2/3, predicted non-organ-confined disease (OR=1.58). Older age was associated with non-organ-confined disease (OR=1.02), as was greater PSA (OR=1.12). DICE-S equation x=ln (p/1-p)=-3.627+0.019 (age)+0.109 (PSA)+1.087 (bGleason=7)+1.180 (bGleason >7)+0.459 (clinical T stage >T1), where p=(e(x))/(1+e(x)). A concordance index (prediction accuracy) of 0.73 was reached on internal validation. Using the DICE-S score, age, PSA, biopsy Gleason sum and clinical tumor stage, we can predict non-organ-confined disease in radical prostatectomy at an acceptable accuracy. Preoperative information on disease stage may aid in treatment decisions and surgical approach.

Duke Scholars

Published In

Prostate Cancer Prostatic Dis

DOI

EISSN

1476-5608

Publication Date

September 2010

Volume

13

Issue

3

Start / End Page

248 / 251

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Survival Rate
  • Prostatic Neoplasms
  • Prostatectomy
  • Prostate-Specific Antigen
  • Prognosis
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Caire, A. A., Sun, L., Lack, B. D., Lum, K., Tang, P., Stackhouse, D. A., … Moul, J. W. (2010). Predicting non-organ-confined prostate cancer in men diagnosed after 2000. Prostate Cancer Prostatic Dis, 13(3), 248–251. https://doi.org/10.1038/pcan.2010.15
Caire, A. A., L. Sun, B. D. Lack, K. Lum, P. Tang, D. A. Stackhouse, C. N. Robertson, et al. “Predicting non-organ-confined prostate cancer in men diagnosed after 2000.Prostate Cancer Prostatic Dis 13, no. 3 (September 2010): 248–51. https://doi.org/10.1038/pcan.2010.15.
Caire AA, Sun L, Lack BD, Lum K, Tang P, Stackhouse DA, et al. Predicting non-organ-confined prostate cancer in men diagnosed after 2000. Prostate Cancer Prostatic Dis. 2010 Sep;13(3):248–51.
Caire, A. A., et al. “Predicting non-organ-confined prostate cancer in men diagnosed after 2000.Prostate Cancer Prostatic Dis, vol. 13, no. 3, Sept. 2010, pp. 248–51. Pubmed, doi:10.1038/pcan.2010.15.
Caire AA, Sun L, Lack BD, Lum K, Tang P, Stackhouse DA, Robertson CN, Mouraviev V, Polascik TJ, Albala DM, Moul JW. Predicting non-organ-confined prostate cancer in men diagnosed after 2000. Prostate Cancer Prostatic Dis. 2010 Sep;13(3):248–251.

Published In

Prostate Cancer Prostatic Dis

DOI

EISSN

1476-5608

Publication Date

September 2010

Volume

13

Issue

3

Start / End Page

248 / 251

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Survival Rate
  • Prostatic Neoplasms
  • Prostatectomy
  • Prostate-Specific Antigen
  • Prognosis
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Humans