Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Persistent antibody depletion after rituximab in three children with autoimmune cytopenias.

Publication ,  Journal Article
Adeli, MMG; Eichner, BH; Thornburg, C; Williams, L
Published in: Pediatr Hematol Oncol
November 2009

We report 3 children who developed persistent antibody depletion and abnormal response to bacteriophage after rituximab treatment for autoimmune cytopenias. Whether these patients have developed immunodeficiency secondary to an underlying disease process, to rituximab, or both, is not understood. Rituximab is an efficacious drug for a number of pediatric conditions. However, some patients who receive the drug have prolonged suppression or absence of B-cell function. Families should be counseled of this possibility prior to therapy. Patients should have baseline measurement of quantitative immunoglobulins and specific antibody levels and should be monitored for long term changes in immune function after rituximab.

Duke Scholars

Published In

Pediatr Hematol Oncol

DOI

EISSN

1521-0669

Publication Date

November 2009

Volume

26

Issue

8

Start / End Page

566 / 572

Location

England

Related Subject Headings

  • Rituximab
  • Pancytopenia
  • Oncology & Carcinogenesis
  • Male
  • Infant
  • Immunosuppression Therapy
  • Immunologic Deficiency Syndromes
  • Humans
  • Female
  • Child
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Adeli, M. M. G., Eichner, B. H., Thornburg, C., & Williams, L. (2009). Persistent antibody depletion after rituximab in three children with autoimmune cytopenias. Pediatr Hematol Oncol, 26(8), 566–572. https://doi.org/10.3109/08880010903271697
Adeli, Mehdi Mohammad G., Brian H. Eichner, Courtney Thornburg, and Larry Williams. “Persistent antibody depletion after rituximab in three children with autoimmune cytopenias.Pediatr Hematol Oncol 26, no. 8 (November 2009): 566–72. https://doi.org/10.3109/08880010903271697.
Adeli MMG, Eichner BH, Thornburg C, Williams L. Persistent antibody depletion after rituximab in three children with autoimmune cytopenias. Pediatr Hematol Oncol. 2009 Nov;26(8):566–72.
Adeli, Mehdi Mohammad G., et al. “Persistent antibody depletion after rituximab in three children with autoimmune cytopenias.Pediatr Hematol Oncol, vol. 26, no. 8, Nov. 2009, pp. 566–72. Pubmed, doi:10.3109/08880010903271697.
Adeli MMG, Eichner BH, Thornburg C, Williams L. Persistent antibody depletion after rituximab in three children with autoimmune cytopenias. Pediatr Hematol Oncol. 2009 Nov;26(8):566–572.

Published In

Pediatr Hematol Oncol

DOI

EISSN

1521-0669

Publication Date

November 2009

Volume

26

Issue

8

Start / End Page

566 / 572

Location

England

Related Subject Headings

  • Rituximab
  • Pancytopenia
  • Oncology & Carcinogenesis
  • Male
  • Infant
  • Immunosuppression Therapy
  • Immunologic Deficiency Syndromes
  • Humans
  • Female
  • Child