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Proteoglycan signaling co-receptors: roles in cell adhesion, migration and invasion.

Publication ,  Journal Article
Mythreye, K; Blobe, GC
Published in: Cell Signal
November 2009

Signaling co-receptors are diverse, multifunctional components of most major signaling pathways, with roles in mediating and regulating signaling in both physiological and pathophysiological circumstances. Many of these signaling co-receptors, including CD44, glypicans, neuropilins, syndecans and TssRIII/betaglycan are also proteoglycans. Like other co-receptors, these proteoglycan signaling co-receptors can bind multiple ligands, promoting the formation of receptor signaling complexes and regulating signaling at the cell surface. The proteoglycan signaling co-receptors can also function as structural molecules to regulate adhesion, cell migration, morphogenesis and differentiation. Through a balance of these signaling and structural roles, proteoglycan signaling co-receptors can have either tumor promoting or tumor suppressing functions. Defining the role and mechanism of action of these proteoglycan signaling co-receptors should enable more effective targeting of these co-receptors and their respective pathways for the treatment of human disease.

Duke Scholars

Published In

Cell Signal

DOI

EISSN

1873-3913

Publication Date

November 2009

Volume

21

Issue

11

Start / End Page

1548 / 1558

Location

England

Related Subject Headings

  • Signal Transduction
  • Receptors, Cell Surface
  • Proteoglycans
  • Neoplasm Invasiveness
  • Humans
  • Cell Movement
  • Cell Adhesion
  • Biochemistry & Molecular Biology
  • 3101 Biochemistry and cell biology
  • 1116 Medical Physiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mythreye, K., & Blobe, G. C. (2009). Proteoglycan signaling co-receptors: roles in cell adhesion, migration and invasion. Cell Signal, 21(11), 1548–1558. https://doi.org/10.1016/j.cellsig.2009.05.001
Mythreye, Karthikeyan, and Gerard C. Blobe. “Proteoglycan signaling co-receptors: roles in cell adhesion, migration and invasion.Cell Signal 21, no. 11 (November 2009): 1548–58. https://doi.org/10.1016/j.cellsig.2009.05.001.
Mythreye K, Blobe GC. Proteoglycan signaling co-receptors: roles in cell adhesion, migration and invasion. Cell Signal. 2009 Nov;21(11):1548–58.
Mythreye, Karthikeyan, and Gerard C. Blobe. “Proteoglycan signaling co-receptors: roles in cell adhesion, migration and invasion.Cell Signal, vol. 21, no. 11, Nov. 2009, pp. 1548–58. Pubmed, doi:10.1016/j.cellsig.2009.05.001.
Mythreye K, Blobe GC. Proteoglycan signaling co-receptors: roles in cell adhesion, migration and invasion. Cell Signal. 2009 Nov;21(11):1548–1558.
Journal cover image

Published In

Cell Signal

DOI

EISSN

1873-3913

Publication Date

November 2009

Volume

21

Issue

11

Start / End Page

1548 / 1558

Location

England

Related Subject Headings

  • Signal Transduction
  • Receptors, Cell Surface
  • Proteoglycans
  • Neoplasm Invasiveness
  • Humans
  • Cell Movement
  • Cell Adhesion
  • Biochemistry & Molecular Biology
  • 3101 Biochemistry and cell biology
  • 1116 Medical Physiology