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Statistical and graphical evaluation of erythrocyte volume distributions.

Publication ,  Journal Article
McLaren, CE; Brittenham, GM; Hasselblad, V
Published in: Am J Physiol
April 1987

A protocol for the statistical and graphical evaluation of erythrocyte volume distributions has been developed using expectation-maximization methods for distribution parameter estimation. In a reference sample group of 50 healthy individuals, none of the red cell volume distributions determined by an aperture impedance method differed significantly from a log normal model. Measurements in 211 patients with anemia provided evidence that similar statistical methods could be used for the characterization of abnormal red cell volume distributions. Graphical displays accurately summarize the quantitative information derived from the analysis of volume distributions and show a reference distribution fitted to the observed distribution against the range of distributions found in healthy individuals. This protocol provides a specific, statistically valid implementation of the general principles for the analysis of cell volume distributions proposed by the International Committee for Standardization in Hematology.

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Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

April 1987

Volume

252

Issue

4 Pt 2

Start / End Page

H857 / H866

Location

United States

Related Subject Headings

  • Statistics as Topic
  • Male
  • Humans
  • Female
  • Erythrocytes
  • Erythrocyte Volume
  • Erythrocyte Count
  • Cardiovascular System & Hematology
  • Anemia
 

Citation

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McLaren, C. E., Brittenham, G. M., & Hasselblad, V. (1987). Statistical and graphical evaluation of erythrocyte volume distributions. Am J Physiol, 252(4 Pt 2), H857–H866. https://doi.org/10.1152/ajpheart.1987.252.4.H857
McLaren, C. E., G. M. Brittenham, and V. Hasselblad. “Statistical and graphical evaluation of erythrocyte volume distributions.Am J Physiol 252, no. 4 Pt 2 (April 1987): H857–66. https://doi.org/10.1152/ajpheart.1987.252.4.H857.
McLaren CE, Brittenham GM, Hasselblad V. Statistical and graphical evaluation of erythrocyte volume distributions. Am J Physiol. 1987 Apr;252(4 Pt 2):H857–66.
McLaren, C. E., et al. “Statistical and graphical evaluation of erythrocyte volume distributions.Am J Physiol, vol. 252, no. 4 Pt 2, Apr. 1987, pp. H857–66. Pubmed, doi:10.1152/ajpheart.1987.252.4.H857.
McLaren CE, Brittenham GM, Hasselblad V. Statistical and graphical evaluation of erythrocyte volume distributions. Am J Physiol. 1987 Apr;252(4 Pt 2):H857–H866.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

April 1987

Volume

252

Issue

4 Pt 2

Start / End Page

H857 / H866

Location

United States

Related Subject Headings

  • Statistics as Topic
  • Male
  • Humans
  • Female
  • Erythrocytes
  • Erythrocyte Volume
  • Erythrocyte Count
  • Cardiovascular System & Hematology
  • Anemia