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Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma.

Publication ,  Journal Article
Liu, Y; Melin, BS; Rajaraman, P; Wang, Z; Linet, M; Shete, S; Amos, CI; Lau, CC; Scheurer, ME; Tsavachidis, S; Armstrong, GN; Houlston, RS ...
Published in: Hum Genet
September 2012

The risk of glioma has consistently been shown to be increased twofold in relatives of patients with primary brain tumors (PBT). A recent genome-wide linkage study of glioma families provided evidence for a disease locus on 17q12-21.32, with the possibility of four additional risk loci at 6p22.3, 12p13.33-12.1, 17q22-23.2, and 18q23. To identify the underlying genetic variants responsible for the linkage signals, we compared the genotype frequencies of 5,122 SNPs mapping to these five regions in 88 glioma cases with and 1,100 cases without a family history of PBT (discovery study). An additional series of 84 familial and 903 non-familial cases were used to replicate associations. In the discovery study, 12 SNPs showed significant associations with family history of PBT (P < 0.001). In the replication study, two of the 12 SNPs were confirmed: 12p13.33-12.1 PRMT8 rs17780102 (P = 0.031) and 17q12-21.32 SPOP rs650461 (P = 0.025). In the combined analysis of discovery and replication studies, the strongest associations were attained at four SNPs: 12p13.33-12.1 PRMT8 rs17780102 (P = 0.0001), SOX5 rs7305773 (P = 0.0001) and STKY1 rs2418087 (P = 0.0003), and 17q12-21.32 SPOP rs6504618 (P = 0.0006). Further, a significant gene-dosage effect was found for increased risk of family history of PBT with these four SNPs in the combined data set (P(trend) <1.0 × 10(-8)). The results support the linkage finding that some loci in the 12p13.33-12.1 and 17q12-q21.32 may contribute to gliomagenesis and suggest potential target genes underscoring linkage signals.

Duke Scholars

Published In

Hum Genet

DOI

EISSN

1432-1203

Publication Date

September 2012

Volume

131

Issue

9

Start / End Page

1507 / 1517

Location

Germany

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Humans
  • Haplotypes
  • Glioma
  • Genetics & Heredity
  • Genetic Predisposition to Disease
  • Female
  • Chromosome Mapping
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liu, Y., Melin, B. S., Rajaraman, P., Wang, Z., Linet, M., Shete, S., … Bondy, M. L. (2012). Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma. Hum Genet, 131(9), 1507–1517. https://doi.org/10.1007/s00439-012-1187-x
Liu, Yanhong, Beatrice S. Melin, Preetha Rajaraman, Zhaoming Wang, Martha Linet, Sanjay Shete, Christopher I. Amos, et al. “Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma.Hum Genet 131, no. 9 (September 2012): 1507–17. https://doi.org/10.1007/s00439-012-1187-x.
Liu Y, Melin BS, Rajaraman P, Wang Z, Linet M, Shete S, et al. Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma. Hum Genet. 2012 Sep;131(9):1507–17.
Liu, Yanhong, et al. “Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma.Hum Genet, vol. 131, no. 9, Sept. 2012, pp. 1507–17. Pubmed, doi:10.1007/s00439-012-1187-x.
Liu Y, Melin BS, Rajaraman P, Wang Z, Linet M, Shete S, Amos CI, Lau CC, Scheurer ME, Tsavachidis S, Armstrong GN, Houlston RS, Hosking FJ, Claus EB, Barnholtz-Sloan J, Lai R, Il’yasova D, Schildkraut J, Sadetzki S, Johansen C, Bernstein JL, Olson SH, Jenkins RB, LaChance D, Vick NA, Wrensch M, Davis F, McCarthy BJ, Andersson U, Thompson PA, Chanock S, Gliogene Consortium, Bondy ML. Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma. Hum Genet. 2012 Sep;131(9):1507–1517.
Journal cover image

Published In

Hum Genet

DOI

EISSN

1432-1203

Publication Date

September 2012

Volume

131

Issue

9

Start / End Page

1507 / 1517

Location

Germany

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Humans
  • Haplotypes
  • Glioma
  • Genetics & Heredity
  • Genetic Predisposition to Disease
  • Female
  • Chromosome Mapping