Skip to main content
Journal cover image

Low prevalence of Pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia.

Publication ,  Journal Article
Taylor, SM; Meshnick, SR; Worodria, W; Andama, A; Davis, JL; Cattamanchi, A; den Boon, S; Yoo, SD; Goodman, CD; Huang, L ...
Published in: Diagn Microbiol Infect Dis
February 2012

Pneumocystis jirovecii is an important opportunistic infection in human immunodeficiency virus (HIV)-infected patients. In the developed world, P. jirovecii epidemiology is marked by frequent colonization in immunosuppressed patients, but data on the prevalence of colonization are very limited in sub-Saharan Africa, where the majority of persons living with HIV reside. Our objective was to describe the epidemiology of P. jirovecii colonization among HIV-positive patients in a cross-sectional, hospital-based study of patients admitted with suspected pneumonia in Kampala, Uganda. P. jirovecii was detectable in bronchoalveolar lavage fluid from 7 (6%) of 124 consecutive patients with non-Pneumocystis pneumonia. Colonization was not associated with patient demographic or clinical information. This prevalence is substantially lower than in published studies in the developed world and suggests that there is a limited reservoir of organisms for clinical infections in this Ugandan population. These findings may partially explain the low incidence of Pneumocystis pneumonia in Uganda and other sub-Saharan African countries.

Duke Scholars

Published In

Diagn Microbiol Infect Dis

DOI

EISSN

1879-0070

Publication Date

February 2012

Volume

72

Issue

2

Start / End Page

139 / 143

Location

United States

Related Subject Headings

  • Uganda
  • Prevalence
  • Pneumonia
  • Pneumocystis carinii
  • Pneumocystis Infections
  • Microbiology
  • Male
  • Humans
  • HIV Infections
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Taylor, S. M., Meshnick, S. R., Worodria, W., Andama, A., Davis, J. L., Cattamanchi, A., … International HIV-associated Opportunistic Pneumonias (IHOP) Study. (2012). Low prevalence of Pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia. Diagn Microbiol Infect Dis, 72(2), 139–143. https://doi.org/10.1016/j.diagmicrobio.2011.10.009
Journal cover image

Published In

Diagn Microbiol Infect Dis

DOI

EISSN

1879-0070

Publication Date

February 2012

Volume

72

Issue

2

Start / End Page

139 / 143

Location

United States

Related Subject Headings

  • Uganda
  • Prevalence
  • Pneumonia
  • Pneumocystis carinii
  • Pneumocystis Infections
  • Microbiology
  • Male
  • Humans
  • HIV Infections
  • Female