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Physiological and psychosocial factors that predict HIV-related fatigue.

Publication ,  Journal Article
Barroso, J; Hammill, BG; Leserman, J; Salahuddin, N; Harmon, JL; Pence, BW
Published in: AIDS Behav
December 2010

Fatigue is one of the most common and debilitating symptoms experienced by HIV-infected people. We report the results of our longitudinal analysis of physiological and psychosocial factors that were thought to predict changes in HIV-related fatigue in 128 participants over a 1-year period, in an effort to sort out the complex interplay among a comprehensive set of physiological and psychosocial variables. Physiological measures included hepatic function (aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transpeptidase, alkaline phosphatase, total bilirubin, hepatitis C status), thyroid function (thyroid stimulating hormone, thyroxine), HIV viral load, immunologic function (CD4, CD8, CD4/CD8 ratio, CD16, CD8CD38), gonadal function (testosterone, dehydroepiandrosterone), hematologic function (hemoglobin, hematocrit, serum erythropoietin), and cellular injury (lactic acid). Psychosocial measures included childhood and adult trauma, anxiety, depression, social support, stressful life events, and post-traumatic stress disorder (PTSD). Unemployment, not being on antiretroviral therapy, having fewer years since HIV diagnosis, more childhood trauma, more stressful life events, less social support, and more psychological distress (e.g., PTSD, anxiety and depression) put HIV-infected persons at risk for greater fatigue intensity and fatigue-related impairment in functioning during 1-year follow-up. Physiological variables did not predict greater fatigue. Stressful life events had both direct and indirect effects on fatigue.

Duke Scholars

Published In

AIDS Behav

DOI

EISSN

1573-3254

Publication Date

December 2010

Volume

14

Issue

6

Start / End Page

1415 / 1427

Location

United States

Related Subject Headings

  • Young Adult
  • Viral Load
  • Stress, Psychological
  • Stress Disorders, Post-Traumatic
  • Social Support
  • Severity of Illness Index
  • Public Health
  • Psychiatric Status Rating Scales
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Barroso, J., Hammill, B. G., Leserman, J., Salahuddin, N., Harmon, J. L., & Pence, B. W. (2010). Physiological and psychosocial factors that predict HIV-related fatigue. AIDS Behav, 14(6), 1415–1427. https://doi.org/10.1007/s10461-010-9691-2
Barroso, Julie, Bradley G. Hammill, Jane Leserman, Naima Salahuddin, James L. Harmon, and Brian Wells Pence. “Physiological and psychosocial factors that predict HIV-related fatigue.AIDS Behav 14, no. 6 (December 2010): 1415–27. https://doi.org/10.1007/s10461-010-9691-2.
Barroso J, Hammill BG, Leserman J, Salahuddin N, Harmon JL, Pence BW. Physiological and psychosocial factors that predict HIV-related fatigue. AIDS Behav. 2010 Dec;14(6):1415–27.
Barroso, Julie, et al. “Physiological and psychosocial factors that predict HIV-related fatigue.AIDS Behav, vol. 14, no. 6, Dec. 2010, pp. 1415–27. Pubmed, doi:10.1007/s10461-010-9691-2.
Barroso J, Hammill BG, Leserman J, Salahuddin N, Harmon JL, Pence BW. Physiological and psychosocial factors that predict HIV-related fatigue. AIDS Behav. 2010 Dec;14(6):1415–1427.
Journal cover image

Published In

AIDS Behav

DOI

EISSN

1573-3254

Publication Date

December 2010

Volume

14

Issue

6

Start / End Page

1415 / 1427

Location

United States

Related Subject Headings

  • Young Adult
  • Viral Load
  • Stress, Psychological
  • Stress Disorders, Post-Traumatic
  • Social Support
  • Severity of Illness Index
  • Public Health
  • Psychiatric Status Rating Scales
  • Middle Aged
  • Male