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Quantification of prostate and seminal vesicle interfraction variation during IMRT.

Publication ,  Journal Article
Frank, SJ; Dong, L; Kudchadker, RJ; De Crevoisier, R; Lee, AK; Cheung, R; Choi, S; O'Daniel, J; Tucker, SL; Wang, H; Kuban, DA
Published in: Int J Radiat Oncol Biol Phys
July 1, 2008

PURPOSE: To quantify the interfraction variability in prostate and seminal vesicle (SV) positions during a course of intensity-modulated radiotherapy (IMRT) using an integrated computed tomography (CT)-linear accelerator system and to assess the impact of rectal and bladder volume changes. METHODS AND MATERIALS: We studied 15 patients who had undergone IMRT for prostate carcinoma. Patients had one pretreatment planning CT scan followed by three in-room CT scans per week using a CT-on-rails system. The prostate, bladder, rectum, and pelvic bony anatomy were contoured in 369 CT scans. Using the planning CT scan as a reference, the volumetric and positional changes were analyzed in the subsequent CT scans. RESULTS: For all 15 patients, the mean systematic internal prostate and SV variation was 0.1 +/- 4.1 mm and 1.2 +/- 7.3 mm in the anteroposterior axis, -0.5 +/- 2.9 mm and -0.7 +/- 4.5 mm in the superoinferior axis, and 0.2 +/- 0.9 mm and -0.9 +/- 1.9 mm in the lateral axis, respectively. The mean magnitude of the three-dimensional displacement vector was 4.6 +/- 3.5 mm for the prostate and 7.6 +/- 4.7 mm for the SVs. The rectal and bladder volume changes during treatment correlated with the anterior and superior displacement of the prostate and SVs. CONCLUSION: The dominant prostate and SV variations occurred in the anteroposterior and superoinferior directions. The systematic prostate and SV variation between the treatment planning CT and daily therapy as a result of the rectal and bladder volume changes emphasizes the need for daily directed target localization and/or immobilization techniques.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

July 1, 2008

Volume

71

Issue

3

Start / End Page

813 / 820

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Seminal Vesicles
  • Reproducibility of Results
  • Radiotherapy, Conformal
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Radiometry
  • Prostatic Neoplasms
  • Prostate
  • Organ Specificity
 

Citation

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ICMJE
MLA
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Frank, S. J., Dong, L., Kudchadker, R. J., De Crevoisier, R., Lee, A. K., Cheung, R., … Kuban, D. A. (2008). Quantification of prostate and seminal vesicle interfraction variation during IMRT. Int J Radiat Oncol Biol Phys, 71(3), 813–820. https://doi.org/10.1016/j.ijrobp.2007.10.028
Frank, Steven J., Lei Dong, Rajat J. Kudchadker, Renaud De Crevoisier, Andrew K. Lee, Rex Cheung, Seungtaek Choi, et al. “Quantification of prostate and seminal vesicle interfraction variation during IMRT.Int J Radiat Oncol Biol Phys 71, no. 3 (July 1, 2008): 813–20. https://doi.org/10.1016/j.ijrobp.2007.10.028.
Frank SJ, Dong L, Kudchadker RJ, De Crevoisier R, Lee AK, Cheung R, et al. Quantification of prostate and seminal vesicle interfraction variation during IMRT. Int J Radiat Oncol Biol Phys. 2008 Jul 1;71(3):813–20.
Frank, Steven J., et al. “Quantification of prostate and seminal vesicle interfraction variation during IMRT.Int J Radiat Oncol Biol Phys, vol. 71, no. 3, July 2008, pp. 813–20. Pubmed, doi:10.1016/j.ijrobp.2007.10.028.
Frank SJ, Dong L, Kudchadker RJ, De Crevoisier R, Lee AK, Cheung R, Choi S, O’Daniel J, Tucker SL, Wang H, Kuban DA. Quantification of prostate and seminal vesicle interfraction variation during IMRT. Int J Radiat Oncol Biol Phys. 2008 Jul 1;71(3):813–820.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

July 1, 2008

Volume

71

Issue

3

Start / End Page

813 / 820

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Seminal Vesicles
  • Reproducibility of Results
  • Radiotherapy, Conformal
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Radiometry
  • Prostatic Neoplasms
  • Prostate
  • Organ Specificity