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Dosimetric comparison of four target alignment methods for prostate cancer radiotherapy.

Publication ,  Journal Article
O'Daniel, JC; Dong, L; Zhang, L; de Crevoisier, R; Wang, H; Lee, AK; Cheung, R; Tucker, SL; Kudchadker, RJ; Bonnen, MD; Cox, JD; Mohan, R; Kuban, DA
Published in: Int J Radiat Oncol Biol Phys
November 1, 2006

PURPOSE: The aim of this study was to compare the dosimetric consequences of 4 treatment delivery techniques for prostate cancer patients treated with intensity-modulated radiotherapy (IMRT). METHODS AND MATERIALS: During an 8-week course of radiotherapy, 10 patients underwent computed tomography (CT) scans 3 times per week (243 total) before daily treatment with a CT-linear accelerator. Treatment delivery was simulated by realigning a fixed-margin treatment plan on each CT scan and calculating doses. The alignment methods were those based on the following: skin marks, bony registration, ultrasonography (US), and in-room CT. For the last two methods, prostate was the alignment target. The dosimetric effects of these alignment methods on the prostate, seminal vesicles, rectum, and bladder were compared. The average daily minimum dose to 0.1 cm3 was used as the metric for target coverage. RESULTS: Skin and bone alignments provided acceptable prostate coverage for only 70% of patients, US alignment for 90%, and CT alignment for 100%. CT-based alignment of the prostate provided seminal vesicle (SV) coverage of > or = 69 Gy for all patients; US and bone alignments provided SV coverage of > or = 60 Gy. This SV coverage may be acceptable for early-stage cancer (equivalent SV dose = 55.8 Gy at 1.8 Gy per fraction), but unacceptable for late-stage cancer (SV dose = 75.6 Gy). At 75.6 Gy, the acceptable rate for SV coverage was 40% for skin and bone alignments, 70% for US, and 80% for CT. CONCLUSIONS: Direct target alignment methods (US and CT) provided better target coverage. CT-guided alignment provided the best and most consistent dosimetric coverage. A larger planning target volume margin is needed for SV coverage when the alignment target is the prostate.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

November 1, 2006

Volume

66

Issue

3

Start / End Page

883 / 891

Location

United States

Related Subject Headings

  • Urinary Bladder
  • Ultrasonography
  • Tomography, X-Ray Computed
  • Seminal Vesicles
  • Rectum
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Prostatic Neoplasms
  • Prostate
 

Citation

APA
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ICMJE
MLA
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O’Daniel, J. C., Dong, L., Zhang, L., de Crevoisier, R., Wang, H., Lee, A. K., … Kuban, D. A. (2006). Dosimetric comparison of four target alignment methods for prostate cancer radiotherapy. Int J Radiat Oncol Biol Phys, 66(3), 883–891. https://doi.org/10.1016/j.ijrobp.2006.06.044
O’Daniel, Jennifer C., Lei Dong, Lifei Zhang, Renaud de Crevoisier, He Wang, Andrew K. Lee, Rex Cheung, et al. “Dosimetric comparison of four target alignment methods for prostate cancer radiotherapy.Int J Radiat Oncol Biol Phys 66, no. 3 (November 1, 2006): 883–91. https://doi.org/10.1016/j.ijrobp.2006.06.044.
O’Daniel JC, Dong L, Zhang L, de Crevoisier R, Wang H, Lee AK, et al. Dosimetric comparison of four target alignment methods for prostate cancer radiotherapy. Int J Radiat Oncol Biol Phys. 2006 Nov 1;66(3):883–91.
O’Daniel, Jennifer C., et al. “Dosimetric comparison of four target alignment methods for prostate cancer radiotherapy.Int J Radiat Oncol Biol Phys, vol. 66, no. 3, Nov. 2006, pp. 883–91. Pubmed, doi:10.1016/j.ijrobp.2006.06.044.
O’Daniel JC, Dong L, Zhang L, de Crevoisier R, Wang H, Lee AK, Cheung R, Tucker SL, Kudchadker RJ, Bonnen MD, Cox JD, Mohan R, Kuban DA. Dosimetric comparison of four target alignment methods for prostate cancer radiotherapy. Int J Radiat Oncol Biol Phys. 2006 Nov 1;66(3):883–891.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

November 1, 2006

Volume

66

Issue

3

Start / End Page

883 / 891

Location

United States

Related Subject Headings

  • Urinary Bladder
  • Ultrasonography
  • Tomography, X-Ray Computed
  • Seminal Vesicles
  • Rectum
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Prostatic Neoplasms
  • Prostate