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Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing.

Publication ,  Journal Article
Hariri, AR; Drabant, EM; Weinberger, DR
Published in: Biological psychiatry
May 2006

Advances in molecular biology and neuroimaging have provided a unique opportunity to explore the relationships between genes, brain, and behavior. In this review, we will briefly outline the rationale for studying genetic effects on brain function with neuroimaging. We will then use studies of genetically driven variation in serotonin transporter function on corticolimbic structure and function to highlight the effectiveness of this strategy to delineate biological pathways and mechanisms by which individual differences in brain function emerge and potentially bias behavior and risk for psychiatric illness. In a series of studies, a relatively frequent regulatory variant of the human serotonin transporter gene (5-HTTLPR) has been demonstrated to bias the reactivity of the amygdala to salient environmental cues. Moreover, the 5-HTTLPR affects the development of a broader corticolimbic circuit and alters the functional integration of emotional information between the amygdala and medial prefrontal cortex. In turn, corticolimbic circuit function predicts individual differences in an experimental index of temperamental anxiety and, thus, might reflect a predictive biological marker of increased risk for mood disorders associated with the 5-HTTLPR.

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Published In

Biological psychiatry

DOI

EISSN

1873-2402

ISSN

0006-3223

Publication Date

May 2006

Volume

59

Issue

10

Start / End Page

888 / 897

Related Subject Headings

  • Synaptic Transmission
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Psychiatry
  • Prefrontal Cortex
  • Polymorphism, Genetic
  • Neural Pathways
  • Mood Disorders
  • Humans
  • Genetic Variation
 

Citation

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Hariri, A. R., Drabant, E. M., & Weinberger, D. R. (2006). Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biological Psychiatry, 59(10), 888–897. https://doi.org/10.1016/j.biopsych.2005.11.005
Hariri, Ahmad R., Emily M. Drabant, and Daniel R. Weinberger. “Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing.Biological Psychiatry 59, no. 10 (May 2006): 888–97. https://doi.org/10.1016/j.biopsych.2005.11.005.
Hariri, Ahmad R., et al. “Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing.Biological Psychiatry, vol. 59, no. 10, May 2006, pp. 888–97. Epmc, doi:10.1016/j.biopsych.2005.11.005.
Journal cover image

Published In

Biological psychiatry

DOI

EISSN

1873-2402

ISSN

0006-3223

Publication Date

May 2006

Volume

59

Issue

10

Start / End Page

888 / 897

Related Subject Headings

  • Synaptic Transmission
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Psychiatry
  • Prefrontal Cortex
  • Polymorphism, Genetic
  • Neural Pathways
  • Mood Disorders
  • Humans
  • Genetic Variation